antibody

SLC22A12 Polyclonal Antibody

MBS2529149

0.02 mL

110 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

SLC22A12 Polyclonal Antibody

[SLC22A12]

[RST; OAT4L; URAT1]

[solute carrier family 22 member 12 isoform d; Solute carrier family 22 member 12; solute carrier family 22 member 12; organic anion transporter 4-like protein; renal-specific transporter; solute carrier family 22 (organic anion/cation transporter), member 12; urate anion exchanger 1; urate transporter 1; solute carrier family 22 (organic anion/urate transporter), member 12; Organic anion transporter 4-like protein; Renal-specific transporter; RST; Urate anion exchanger 1]

[SLC22A12]

[SLC22A12; SLC22A12; RST; OAT4L; URAT1; OATL4; URAT1; RST]

S22AC_HUMAN

Polyclonal

IgG

Rabbit

Human

445

Affinity purification

PBS with 0.05% sodium azide, 50% glycerol, PH7.3

Store at -20°C. Avoid freeze / thaw cycles.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:200-1:1000. IHC: 1:25-1:100

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (IHC)

Immunogen: Synthetic peptide of human SLC22A12

The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants.

444299638

NP_653186

NM_001276327.1

Q96S37

60kDa

Organic Anion Transport Pathway (161074); Organic Cation/anion/zwitterion Transport Pathway (161072); SLC-mediated Transmembrane Transport Pathway (119558); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (119571)

The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

SLC22A12: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Defects in SLC22A12 are the cause of hypouricemia renal type 1 (RHUC1). A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Transporter. Chromosomal Location of Human Ortholog: 11q13.1. Cellular Component: brush border membrane; apical plasma membrane; integral to membrane; plasma membrane. Molecular Function: urate transmembrane transporter activity; PDZ domain binding. Biological Process: response to drug; urate transport; urate metabolic process; cellular homeostasis; organic acid transport; transmembrane transport. Disease: Hypouricemia, Renal, 1

0.02 mL

110 USD

0.06 mL

150

0.12 mL

225

0.2 mL

360