IGFBP7 Antibody | MyBioSource MBS2529143 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IGFBP7 Antibody

catalog :

MBS2529143

quantity :

0.06 mL

price :

195 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Mouse colon tissue were subjected to SDS-PAGE followed by western blot with IGFBP7 Polyclonal Antibody at dilution of 1:300

image 2 :

Immunohistochemistry of paraffinembedded human liver tissue slide using IGFBP7 Polyclonal Antibody at dilution of 1:50 (under 40x lens)

image 3 :

Immunohistochemistry of paraffinembedded human liver cancer tissue slide using IGFBP7 Polyclonal Antibody at dilution of 1:50 (under 40x lens)

product information

catalog number :

MBS2529143

products type :

Antibody

products full name :

IGFBP7 Antibody

products short name :

[IGFBP7]

products name syn :

[FSTL2, IBP 7, IGF binding protein 7, IGFBP 7, IGFBP 7v, IGFBP rP1, IGFBP7, IGFBPRP1, MAC25, MAC25 protein, PGI2 stimulating factor, PSF, TAF, Tumor derived adhesion factor]

other names :

[insulin-like growth factor-binding protein 7 isoform 2; Insulin-like growth factor-binding protein 7; insulin-like growth factor-binding protein 7; IGF-binding protein 7; IGFBP-rP1; PGI2-stimulating factor; angiomodulin; prostacyclin-stimulating factor; tumor-derived adhesion factor; insulin-like growth factor binding protein 7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor; TAF]

products gene name :

[IGFBP7]

other gene names :

[IGFBP7; IGFBP7; AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1; MAC25; PSF; IBP-7; IGF-binding protein 7; IGFBP-7; TAF]

uniprot entry name :

IBP7_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

279

purity :

Antigen affinity purification

storage stability :

Store at -20°C. Avoid freeze / thaw cycles

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:200-1:1000. IHC: 1:20-1:200

image1 heading :

SDS-PAGE

image2 heading :

Immunohistichemistry

image3 heading :

Immunohistichemistry

other info1 :

Immunogen: Peptide

other info2 :

Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Calculated MW: 29kDa. Observed MW: Refer to the figures.

products description :

IGFBP7, also named as MAC25, PSF, IBP-7 and TAF, binds IGF-I and IGF-II with a relatively low affinity. IGFBP7 stimulates prostacyclin (PGI2) production. IGFBP7 stimulates cell adhesion.

ncbi gi num :

359465608

ncbi acc num :

NM_001553

ncbi gb acc num :

NM_001253835.1

uniprot acc num :

Q16270

ncbi pathways :

Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); Senescence And Autophagy Pathway (198780); Senescence-Associated Secretory Phenotype (SASP) Pathway (905996)

ncbi summary :

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

uniprot summary :

IGFBP7: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS). RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of beading along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. Protein type: Secreted, signal peptide; Cell adhesion; Secreted; Cell cycle regulation. Chromosomal Location of Human Ortholog: 4q12. Cellular Component: extracellular matrix; extracellular space; extracellular region. Molecular Function: insulin-like growth factor binding; protein binding. Biological Process: negative regulation of cell proliferation; response to retinoic acid; response to cortisol stimulus; response to heat; regulation of steroid biosynthetic process; regulation of cell growth; cell adhesion; inner ear development; embryo implantation; cellular response to hormone stimulus. Disease: Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis

size1 :

0.06 mL

price1 :

195 USD

size2 :

0.12 mL

price2 :

270

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage