LARS Antibody | MyBioSource MBS2528450 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LARS Antibody

catalog :

MBS2528450

quantity :

0.06 mL

price :

195 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Raji cells were subjected to SDS PAGE followed by western blot : with LARS antibody at dilution of 1:2000

image 2 :

Immunohistochemical of paraffm-embedded human colonusing LARS antibody at dilution of 1:100 (under 40x lens)

image 3 :

Immunofluorescent analysis of HepG2 cells., using LARS antibodyat 1 :25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudo color =DAPI (fluorescent DNA dye)

product information

catalog number :

MBS2528450

products type :

Antibody

products full name :

LARS Antibody

products short name :

[LARS]

products name syn :

[FLJ10595, FLJ21788, hr025Cl, HSPC192,KIAA1352, LARS, LARS1, LeucinetRNA ligase,leucyl tRNA synthetase, LEURS, LEUS, LRS, PIG44, RNTLS]

other names :

[leucine--tRNA ligase, cytoplasmic; Leucine--tRNA ligase, cytoplasmic; leucine--tRNA ligase, cytoplasmic; cytoplasmic leucyl-tRNA synthetase; cytosolic leucyl-tRNA synthetase; leucine tRNA ligase 1, cytoplasmic; leucine translase; leucine-tRNA ligase; leucyl-tRNA synthetase, cytoplasmic; proliferation-inducing gene 44; leucyl-tRNA synthetase; Leucyl-tRNA synthetase; LeuRS]

products gene name :

[LARS]

other gene names :

[LARS; LARS; LRS; LEUS; LFIS; ILFS1; LARS1; LEURS; PIG44; RNTLS; HSPC192; hr025Cl; KIAA1352; LeuRS]

uniprot entry name :

SYLC_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1176

purity :

Antigen affinity purification

storage stability :

Store at -20°C. Avoid freeze / thaw cycles

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

WB 1:1000-1:4000. IHC 1:100-1:400. IF 1:10-1:100

image1 heading :

Testing Data

image2 heading :

Immunohistochemical

image3 heading :

Immunofluorescent

other info1 :

Immunogen: Fusion protein of LARS. Calculated MW: 1176aa; 134kd. Observed MW: 135-140kd

other info2 :

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-130801

products description :

This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed.

ncbi gi num :

108773810

ncbi acc num :

BC151214

ncbi gb acc num :

NM_020117.9

uniprot acc num :

Q9P2J5

ncbi pathways :

Aminoacyl-tRNA Biosynthesis Pathway (83030); Aminoacyl-tRNA Biosynthesis Pathway (424); Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway (413439); Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway (468360); Cytosolic TRNA Aminoacylation Pathway (105981); Gene Expression Pathway (105937); TRNA Aminoacylation Pathway (105980)

ncbi summary :

This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]

uniprot summary :

LARS: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. Belongs to the class-I aminoacyl-tRNA synthetase family. Protein type: Ligase; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; EC 6.1.1.4; Translation. Chromosomal Location of Human Ortholog: 5q32. Cellular Component: cytoplasm; cytosol; nucleus. Molecular Function: methionine-tRNA ligase activity; leucine-tRNA ligase activity; protein binding; ATP binding. Biological Process: leucyl-tRNA aminoacylation; tRNA aminoacylation for protein translation; regulation of translational fidelity; methionyl-tRNA aminoacylation; gene expression. Disease: Infantile Liver Failure Syndrome 1

size1 :

0.06 mL

price1 :

195 USD

size2 :

0.12 mL

price2 :

270

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage