antibody

UCP1 Antibody

MBS2527973

0.06 mL

150 USD

polyclonal

rabbit

nonconjugated

human, mouse

Antibody

UCP1 Antibody

[UCP1]

[UCP; SLC25A7]

[UCP1 protein, partial; Mitochondrial brown fat uncoupling protein 1; mitochondrial brown fat uncoupling protein 1; solute carrier family 25 member 7; thermogenin; uncoupling protein 1 (mitochondrial, proton carrier); Solute carrier family 25 member 7; Thermogenin]

[UCP1]

[UCP1; UCP1; UCP; SLC25A7; SLC25A7; UCP; UCP 1]

UCP1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

Affinity purification

Store at -20°C. Avoid freeze / thaw cycles.

Western Blot (WB)

WB: 1:500-1:2000

Western Blot (WB)

Immunogen: Recombinant protein of human UCP1

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.

46854818

AAH69556.1

33kDa

Adipogenesis Pathway (198832); Electron Transport Chain Pathway (198860); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Metabolism Pathway (477135); Mitochondrial Uncoupling Proteins Pathway (160963); PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450); Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway (105921); The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway (477137)

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]

UCP1: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Belongs to the mitochondrial carrier family. Protein type: Mitochondrial; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 4q28-q31. Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane. Molecular Function: oxidative phosphorylation uncoupler activity. Biological Process: regulation of transcription from RNA polymerase II promoter; cellular metabolic process; proton transport; brown fat cell differentiation; mitochondrial transport. Disease: Obesity

0.06 mL

150 USD

0.12 mL

225

0.2 mL

360