catalog number :
MBS2527198
products full name :
VMP1 Polyclonal Antibody
products short name :
[VMP1]
products name syn :
[EPG3; TANGO5; TMEM49]
other names :
[vacuole membrane protein 1; Vacuole membrane protein 1; vacuole membrane protein 1; ectopic P-granules autophagy protein 3 homolog; transmembrane protein 49; transport and golgi organization 5 homolog; vacuole membrane protein 1; Transmembrane protein 49]
products gene name :
[VMP1]
other gene names :
[VMP1; VMP1; EPG3; TANGO5; TMEM49; TDC1; TMEM49]
uniprot entry name :
VMP1_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Affinity purification
form :
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
storage stability :
Store at -20°C. Avoid freeze / thaw cycles.
tested application :
ELISA (EIA), Immunohistochemistry (IHC)
app notes :
IHC: 1:25-1:100
image1 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Synthetic peptide of human VMP1
products description :
VMP1 is a stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. VMP1 is a transmembrane protein that co-localizes with LC3, a marker of the autophagosomes. It interacts with beclin-1, a mammalian autophagy initiator, through the VMP1-Atg domain, which is essential for autophagosome formation.
ncbi gb acc num :
NM_030938.3
uniprot summary :
VMP1: Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Interacts with BECN1. Interacts with TJP1. Interacts with TP53INP2. Belongs to the VMP1 family. Protein type: Endoplasmic reticulum; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 17q23.1. Cellular Component: ER-Golgi intermediate compartment membrane; membrane; endoplasmic reticulum; integral to membrane; plasma membrane. Molecular Function: protein binding. Biological Process: endoplasmic reticulum organization and biogenesis; cell-cell adhesion; exocytosis; autophagy; regulation of autophagy; Golgi organization and biogenesis; embryo implantation