product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
DBH Polyclonal Antibody
catalog :
MBS2526980
quantity :
0.02 mL
price :
110 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
image
image 1 :
Western Blot analysis of Mouse brain tissue, A172 and Hela cell using DBH Polyclonal Antibody at dilution of 1:200
image 2 :
Immunohistochemistry of paraffin-embedded Human thyroid cancer using DBH Polyclonal Antibody at dilution of 1:70
image 3 :
Immunohistochemistry of paraffin-embedded Human liver cancer using DBH Polyclonal Antibody at dilution of 1:70
product information
catalog number :
MBS2526980
products type :
Antibody
products full name :
DBH Polyclonal Antibody
products short name :
[DBH]
products name syn :
[DBM]
other names :
[dopamine beta-hydroxylase; Dopamine beta-hydroxylase; dopamine beta-hydroxylase; dopamine beta-hydroxylase (dopamine beta-monooxygenase); Dopamine beta-monooxygenaseSoluble dopamine beta-hydroxylase]
products gene name :
[DBH]
other gene names :
[DBH; DBH; DBM]
uniprot entry name :
DOPO_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse.
sequence length :
617
purity :
Antigen affinity purification
storage stability :
Store at -20°C. Avoid freeze/ thaw cycles.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:200-1:1000. IHC: 1:100-1:300
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Recombinant protein of human DBH. Calculated Molecular Weight: 69kDa
other info2 :
Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
products categories :
Neuroscience
products description :
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.
ncbi gi num :
116534900
ncbi acc num :
NP_000778.3
ncbi gb acc num :
NM_000787.3
uniprot acc num :
BC017174
ncbi pathways :
Amine-derived Hormones Pathway (160983); Biogenic Amine Synthesis Pathway (198793); Catecholamine Biosynthesis Pathway (160984); Catecholamine Biosynthesis, Tyrosine = Dopamine = Noradrenaline = Adrenaline Pathway (413357); Catecholamine Biosynthesis, Tyrosine = Dopamine = Noradrenaline = Adrenaline Pathway (468235); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Monoamine Transport Pathway (198851); Tyrosine Metabolism Pathway (82959)
ncbi summary :
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008]
uniprot summary :
DBH: Conversion of dopamine to noradrenaline. Homotetramer composed of two non-covalently bound disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. Belongs to the copper type II ascorbate-dependent monooxygenase family. Protein type: EC 1.14.17.1; Membrane protein, integral; Motility/polarity/chemotaxis; Oxidoreductase; Amino Acid Metabolism - tyrosine; Apoptosis; Cell cycle regulation. Chromosomal Location of Human Ortholog: 9q34. Cellular Component: membrane; cytoplasm; integral to membrane; extracellular region. Molecular Function: copper ion binding; L-ascorbic acid binding; dopamine beta-monooxygenase activity; catalytic activity. Biological Process: fear response; dopamine catabolic process; maternal behavior; response to amphetamine; cytokine production; locomotory behavior; response to pain; leukocyte mediated immunity; behavioral response to ethanol; glucose homeostasis; memory; regulation of cell proliferation; norepinephrine biosynthetic process; synaptic transmission; catecholamine biosynthetic process; homoiothermy; positive regulation of vasoconstriction; visual learning; blood vessel remodeling; leukocyte migration. Disease: Dopamine Beta-hydroxylase Deficiency, Congenital
size1 :
0.02 mL
price1 :
110 USD
size2 :
0.06 mL
price2 :
150
size3 :
0.12 mL
price3 :
225
size4 :
0.2 mL
price4 :
360
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!
related products
browse more products
questions and comments