AXL Antibody | MyBioSource MBS2526926 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

AXL Antibody

catalog :

MBS2526926

quantity :

0.06 mL

price :

195 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

HepG2 cells were subjected to SDS PAGE followed by western blot with AXL Polyclonal Antibody at dilution of 1:1500

product information

catalog number :

MBS2526926

products type :

Antibody

products full name :

AXL Antibody

products short name :

[AXL]

products name syn :

[AXL, AXL oncogene, AXL receptor tyrosine kinase, JTK11, UFO]

other names :

[AXL receptor tyrosine kinase; Tyrosine-protein kinase receptor UFO; tyrosine-protein kinase receptor UFO; AXL oncogene; AXL transforming sequence/gene; AXL receptor tyrosine kinase; AXL oncogene]

products gene name :

[AXL]

other gene names :

[AXL; AXL; ARK; UFO; JTK11; Tyro7; UFO]

uniprot entry name :

UFO_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

894

purity :

Antigen affinity purification

form :

PBS with 0.02% sodium azide, 50% glycerol, pH 7.3

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1:500-1:2000

image1 heading :

Western Blot

other info1 :

Immunogen: Fusion protein of AXL

products description :

Axl, also known as Ufo or Ark, is a receptor tyrosine kinase of the TAM (Tyro3, Axl and Mer) family. Axl is a single-pass type I membrane protein containing two fibronectin type-III domains, two Ig-like C2-type domains and one protein kinase domain. Axl mRNA is widely expressed with highest levels in the heart and skeletal muscle. Gas6 has been identified as a ligand for human Axl. Gas6/Axl signaling plays a role in cell survival, cell proliferation, migration and differentiation. This antibody detects a single band at 140 kDa, which is considered to represent the auto-phosphorylated form of endogenous Axl.

ncbi gi num :

21619004

ncbi acc num :

BC032229

uniprot acc num :

P30530

ncbi mol weight :

Calculated MW: 894aa,98 kDa. Observed MW: 140 kDa

ncbi pathways :

Signal Transduction Pathway (477114); Signaling By VEGF Pathway (106506); VEGFA-VEGFR2 Pathway (1127512)

ncbi summary :

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

uniprot summary :

AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Oncoprotein; Protein kinase, TK; Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Axl family. Chromosomal Location of Human Ortholog: 19q13.1. Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane. Molecular Function: protein binding; protein heterodimerization activity; phosphatidylserine binding; protein-tyrosine kinase activity; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding; myosin heavy chain binding. Biological Process: peptidyl-tyrosine phosphorylation; cell maturation; neuron migration; signal transduction; positive regulation of natural killer cell differentiation; erythrocyte homeostasis; ovulation cycle; natural killer cell differentiation; negative regulation of interferon-gamma production; protein kinase B signaling cascade; negative regulation of neuron apoptosis; inflammatory response; secretion by cell; forebrain cell migration; platelet activation; negative regulation of lymphocyte activation; organ regeneration; vagina development; negative regulation of tumor necrosis factor production; phagocytosis; positive regulation of protein kinase B signaling cascade; cellular response to extracellular stimulus; innate immune response; spermatogenesis; blood vessel remodeling; vascular endothelial growth factor receptor signaling pathway; positive regulation of cytokine and chemokine mediated signaling pathway; apoptotic cell clearance

size1 :

0.06 mL

price1 :

195 USD

size2 :

0.12 mL

price2 :

270

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage