catalog number :
MBS2526916
products full name :
LAG3 Polyclonal Antibody
products short name :
LAG3
products name syn :
CD223
other names :
lymphocyte activation gene 3 protein; Lymphocyte activation gene 3 protein; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Protein FDC; CD_antigen: CD223
products gene name :
LAG3
other gene names :
LAG3; LAG3; CD223; FDC; LAG-3
uniprot entry name :
LAG3_HUMAN
purity :
Affinity purification
storage stability :
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
WB: 1:500-1:2000
products description :
Background/Introduction: Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG4 to
ncbi acc num :
NP_002277.4
ncbi gb acc num :
NM_002286.5
ncbi summary :
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
uniprot summary :
LAG3: Involved in lymphocyte activation. Binds to HLA class-II antigens. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 12p13.32. Cellular Component: integral to membrane; external side of plasma membrane. Molecular Function: transmembrane receptor activity; antigen binding; MHC class II protein binding. Biological Process: cell surface receptor linked signal transduction; negative regulation of interleukin-2 biosynthetic process; positive regulation of natural killer cell mediated cytotoxicity; negative regulation of T cell activation