ID1 Antibody | MyBioSource MBS2526125 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ID1 Antibody

catalog :

MBS2526125

quantity :

0.06 mL

price :

195 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

PC-3 cells were subjected to SDS-PAGE followed by western blot with ID1 antibody at dilutions of 1:500

product information

catalog number :

MBS2526125

products type :

Antibody

products full name :

ID1 Antibody

products short name :

[ID1]

products name syn :

[ID; bHLHb24]

other names :

[Id1; DNA-binding protein inhibitor ID-1; DNA-binding protein inhibitor ID-1; class B basic helix-loop-helix protein 24; dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein); inhibitor of differentiation 1; inhibitor of DNA binding 1, dominant negative helix-loop-helix protein; Class B basic helix-loop-helix protein 24; bHLHb24; Inhibitor of DNA binding 1; Inhibitor of differentiation 1]

products gene name :

[ID1]

other gene names :

[ID1; ID1; ID; bHLHb24; BHLHB24; ID; bHLHb24]

uniprot entry name :

ID1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

154

purity :

Antigen affinity purification

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

WB: 1:200-1:2000

image1 heading :

Testing Data

other info1 :

Immunogen: Fusion protein of ID1. Calculated Molecular Weight: 16kd. Observed Molecular Weight: 20kd

other info2 :

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27186 / sc-27187 / sc-488 / sc-734 / sc-427

products description :

ID (inhibitor of DNA binding) proteins contain helix-loop-helix (HLH) motif and regulate tissue-specific transcription within several cell lineages. They do not bind DNA directly, but inhibit lineage commitment by binding basic helix-hoop-helix (bHLH)transcription factors through their HLH motif. ID1 proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID proteins contribute to cell growth, senescence, differentiation, and angiogenesis.

ncbi gi num :

457785

ncbi acc num :

BC000613

uniprot acc num :

P41134

ncbi mol weight :

15,586 Da

ncbi pathways :

ALK1 Signaling Events Pathway (137968); Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); IL-3 Signaling Pathway (198881); Id Signaling Pathway (198871); Neural Crest Differentiation Pathway (672460); Notch-mediated HES/HEY Network Pathway (169347); Oncogene Induced Senescence Pathway (905992)

ncbi summary :

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

ID1: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription, coactivator/corepressor; DNA-binding. Chromosomal Location of Human Ortholog: 20q11. Cellular Component: nucleoplasm; Golgi apparatus; nucleus. Molecular Function: protein dimerization activity; protein binding; transcription factor activity. Biological Process: circadian rhythm; blood vessel endothelial cell migration; collagen metabolic process; transcription, DNA-dependent; protein destabilization; heart development; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; regulation of angiogenesis; negative regulation of DNA binding; response to antibiotic; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; regulation of MAPKKK cascade; blood vessel morphogenesis; negative regulation of osteoblast differentiation; endothelial cell morphogenesis; angiogenesis; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

size1 :

0.06 mL

price1 :

195 USD

size2 :

0.12 mL

price2 :

270

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage