HEY1 Antibody | MyBioSource MBS2525913 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

HEY1 Antibody

catalog :

MBS2525913

quantity :

0.06 mL

price :

195 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of DU 145 cells using HEY1 Polyclonal Antibody at dilution of 1:3000

image 2 :

Immunohistochemistry of paraffin-embedded human brain using HEY1 Polyclonal Antibody at dilution of 1:100

product information

catalog number :

MBS2525913

products type :

Antibody

products full name :

HEY1 Antibody

products short name :

[HEY1]

products name syn :

[BHLHb31, CHF 2, CHF2, HERP2, HESR 1, HESR1, HEY1, hHRT1, HRT 1, HRT1, OAF1]

other names :

[hairy/enhancer-of-split related with YRPW motif protein 1 isoform c; Hairy/enhancer-of-split related with YRPW motif protein 1; hairy/enhancer-of-split related with YRPW motif protein 1; HES-related repressor protein 1; HES-related repressor protein 2; basic helix-loop-helix protein OAF1; cardiovascular helix-loop-helix factor 2; class B basic helix-loop-helix protein 31; hairy and enhancer of split-related protein 1; hairy-related transcription factor 1; hairy/enhancer-of-split related with YRPW motif 1; hes-related family bHLH transcription factor with YRPW motif 1; Cardiovascular helix-loop-helix factor 2; CHF-2; Class B basic helix-loop-helix protein 31; bHLHb31; HES-related repressor protein 1; Hairy and enhancer of split-related protein 1; HESR-1; Hairy-related transcription factor 1; HRT-1; hHRT1]

products gene name :

[HEY1]

other gene names :

[HEY1; HEY1; CHF2; OAF1; HERP2; HESR1; HRT-1; hHRT1; BHLHb31; BHLHB31; CHF2; HERP2; HESR1; HRT1; CHF-2; bHLHb31; HESR-1; HRT-1; hHRT1]

uniprot entry name :

HEY1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

214

purity :

Affinity purification

form :

PBS with 0.1% sodium azide, 50% glycerol, pH7.3

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

app notes :

WB 1:500-1:2000. IHC 1:20-1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Fusion protein of HEY1

products description :

Hairy/enhancer of split-related proteins are basic helix-loop-helix (bHLH) transcription factors implicated in cell fate decision and boundary formation. And HEY1 is one of such protein. It is the direct downstream effector of Notch signaling which may be required for cardiovascular development. It preferentially bind to the canonical E box sequence 5'-CACGTG-3' and acts as a transcriptional repressor. HEY1 is a 33kDa protein and forms dimer by self-associating.

ncbi gi num :

544583479

ncbi acc num :

NP_001269780.1

ncbi gb acc num :

NM_001282851.1

uniprot acc num :

BC001873

ncbi mol weight :

Calculated MW: 304aa,33 kDa. Observed MW: 32-34 kDa

ncbi pathways :

Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway (771595); Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway (771593); Delta-Notch Signaling Pathway (198879); Disease Pathway (530764); FBXW7 Mutants And NOTCH1 In Cancer Pathway (771596); Heart Development Pathway (198802); NOTCH1 Intracellular Domain Regulates Transcription Pathway (576271); Notch-mediated HES/HEY Network Pathway (169347); Signal Transduction Pathway (477114); Signaling By NOTCH Pathway (106485)

ncbi summary :

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

uniprot summary :

HEY1: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5 - CACGTG-3 . Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Belongs to the HEY family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Nuclear receptor co-regulator; Transcription factor. Chromosomal Location of Human Ortholog: 8q21. Cellular Component: nucleoplasm; cytoplasm; nucleus. Molecular Function: protein dimerization activity; protein binding; transcription factor activity; transcription factor binding. Biological Process: transcription from RNA polymerase II promoter; positive regulation of osteoblast differentiation; Notch signaling pathway; negative regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; negative regulation of transcription from RNA polymerase II promoter; vasculogenesis; negative regulation of transcription, DNA-dependent; anterior/posterior axis specification; osteoblast development

size1 :

0.06 mL

price1 :

195 USD

size2 :

0.12 mL

price2 :

270

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage