product summary
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company name :
MyBioSource
product type :
antibody
product name :
CRKL Polyclonal Antibody
catalog :
MBS2525825
quantity :
0.02 mL
price :
110 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS2525825 image 1
Western Blot analysis of Lovo, Raji and A172 cell using CRKL Polyclonal Antibody at dilution of 1:600
image 2 :
MyBioSource MBS2525825 image 2
Immunohistochemistry of paraffin-embedded Human thyroid cancer using CRKL Polyclonal Antibody at dilution of 1:25
image 3 :
MyBioSource MBS2525825 image 3
Immunohistochemistry of paraffin-embedded Human gastric cancer using CRKL Polyclonal Antibody at dilution of 1:25
product information
catalog number :
MBS2525825
products type :
Antibody
products full name :
CRKL Polyclonal Antibody
products short name :
[CRKL]
other names :
[crk-like protein; Crk-like protein; crk-like protein; v-crk avian sarcoma virus CT10 oncogene homolog-like]
products gene name :
[CRKL]
other gene names :
[CRKL; CRKL]
uniprot entry name :
CRKL_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
303
purity :
Antigen affinity purification
concentration :
2.3mg/mL
storage stability :
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500-1:2000. IHC: 1:25-1:100
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Synthetic peptide of human CRKL. Calculated Molecular Weight: 34kDa
other info2 :
Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
products description :
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
ncbi gi num :
4885153
ncbi acc num :
NP_005198.1
ncbi gb acc num :
NM_005207.3
ncbi mol weight :
34kDa
ncbi pathways :
B Cell Receptor Signaling Pathway (198909); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Chronic Myeloid Leukemia Pathway (83116); Chronic Myeloid Leukemia Pathway (528); Cytokine Signaling In Immune System Pathway (366171); Downstream Signal Transduction Pathway (106385); EGFR1 Signaling Pathway (198782)
ncbi summary :
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
uniprot summary :
CRKL: an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL. Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 22q11.21. Cellular Component: cytosol; endosome. Molecular Function: protein binding; signal transducer activity; SH3/SH2 adaptor activity. Biological Process: anterior/posterior pattern formation; blood vessel development; organ morphogenesis; nerve growth factor receptor signaling pathway; thymus development; activation of MAPKK activity; heart development; Ras protein signal transduction; JNK cascade; parathyroid gland development
size1 :
0.02 mL
price1 :
110 USD
size2 :
0.06 mL
price2 :
150
size3 :
0.12 mL
price3 :
225
size4 :
0.2 mL
price4 :
360
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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