product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
HAAO Antibody
catalog :
MBS2525543
quantity :
0.06 mL
price :
195 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
more info or order :
image
image 1 :
Western Blot analysis of mouse liver tissue with HAAO Polyclonal Antibody at dilution of 1:600
image 2 :
Immunohistochemistry of paraffin-embedded human gliomas tissue slide using HAAO Polyclonal Antibody at dilution of 1:100 (under 40x lens).
image 3 :
Immunofluorescent analysis of HepG2 cells using HAOO Polyclonal Antibody at dilution of 1:50
product information
catalog number :
MBS2525543
products type :
Antibody
products full name :
HAAO Antibody
products short name :
[HAAO]
products name syn :
[3 HAO, HAAO, HAD, HAO]
other names :
[HAAO; 3-hydroxyanthranilate 3,4-dioxygenase; 3-hydroxyanthranilate 3,4-dioxygenase; 3-HAO; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; HAAO; HAD; 3-hydroxyanthranilate 3,4-dioxygenase; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase]
products gene name :
[HAAO]
other gene names :
[HAAO; HAAO; HAO; 3-HAO]
uniprot entry name :
3HAO_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
purity :
Affinity purification
storage stability :
Store at -20°C . Avoid freeze/thaw cycles.
tested application :
WB, IHC, IF, ELISA
app notes :
WB: 1:500-1:1000. IHC: 1:50-1:200. IF: 1:50-1:200
image1 heading :
Western blot (WB)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunofluorescent (IF)
other info1 :
Immunogen: Fusion protein of HAAO. Calculated Molecular Weight: 286aa; 33kd. Observed Molecular Weight: 33kd
other info2 :
Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
products description :
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
ncbi gi num :
48146243
ncbi acc num :
BC029510
uniprot acc num :
P46952
ncbi pathways :
L-kynurenine Degradation Pathway (907939); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); NAD Biosynthesis II (from Tryptophan) Pathway (138368); NAD De Novo Biosynthesis Pathway (142215); Tryptophan Catabolism Pathway (106190); Tryptophan Metabolism Pathway (82964); Tryptophan Metabolism Pathway (198850); Tryptophan Metabolism Pathway (332)
ncbi summary :
3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
uniprot summary :
HAAO: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. Belongs to the 3-HAO family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Amino Acid Metabolism - tryptophan; EC 1.13.11.6; Oxidoreductase. Chromosomal Location of Human Ortholog: 2p21. Cellular Component: mitochondrial membrane; cytosol. Molecular Function: electron carrier activity; ferrous iron binding; oxygen binding; 3-hydroxyanthranilate 3,4-dioxygenase activity. Biological Process: anthranilate metabolic process; response to cadmium ion; response to zinc ion; quinolinate biosynthetic process; tryptophan catabolic process
size1 :
0.06 mL
price1 :
195 USD
size2 :
0.12 mL
price2 :
270
size3 :
0.2 mL
price3 :
435
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!
browse more products
questions and comments