CDK12 Polyclonal Antibody | MyBioSource MBS2525453 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CDK12 Polyclonal Antibody

catalog :

MBS2525453

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CDK12 Polyclonal Antibody at dilution 1:30

image 2 :

Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CDK12 Polyclonal Antibody at dilution 1:30

product information

catalog number :

MBS2525453

products type :

Antibody

products full name :

CDK12 Polyclonal Antibody

products short name :

[CDK12]

products name syn :

[CRK7; CRKR; CRKRS; hCDK12]

other names :

[cyclin-dependent kinase 12 isoform 2; Cyclin-dependent kinase 12; cyclin-dependent kinase 12; CDC2-related protein kinase 7; Cdc2-related kinase, arginine/serine-rich; cell division cycle 2-related protein kinase 7; cell division protein kinase 12; cyclin-dependent kinase 12; Cdc2-related kinase, arginine/serine-rich; CrkRS; Cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; Cell division protein kinase 12; hCDK12]

products gene name :

[CDK12]

other gene names :

[CDK12; CDK12; CRK7; CRKR; CRKRS; CRK7; CRKRS; KIAA0904; CrkRS; CDC2-related protein kinase 7; hCDK12]

uniprot entry name :

CDK12_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1481

purity :

Affinity purification

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

app notes :

IHC: 1:25-1:100

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Synthetic peptide of human CDK12

other info2 :

Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3

products categories :

Cancer

products description :

CrkRS (Cdc2-related kinase, arginine/serine-rich, also designated CRK7 and CRKR) is an ubiquitous protein that appears to localize to the nucleus and link transcription and splicing machinery. CrkRS belongs to the serine/threonine protein kinase family and Cdc2/Cdkx subfamily. CrkRS has extensive proline-rich regions that resemble SH3 and WW domain binding sites, and an RS domain that is characteristic of splicing factors. The protein kinase domain of CrkRS is 89% identical to the CHED protein kinase, also designated CDC2L5 and cell division cycle 2-like 5 (cholinesterase-related cell division controller), however outside the kinase domains the two proteins are unique. Cell cycle control kinases can phosphorylate proteins important for differentiation and apoptosis and provide connections between proliferation, differentiation, apoptosis, and neurocytoskeleton dynamics.

ncbi gi num :

157817073

ncbi acc num :

NP_057591

ncbi gb acc num :

NM_015083.2

uniprot acc num :

Q9NYV4

uniprot summary :

CDK12: a Ser/Thr protein kinase of the CMGC group and CDK family. Phosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Interacts with CCNL1 and CCNL2. Colocalized with nuclear speckles throughout interphase. Has a highly phosphorylated arginine/serine-rich (RS) domain N-terminal to the kinase domain. Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2. Three isoforms of the human protein are produced by alternative splicing. Protein type: Cell cycle regulation; Spliceosome; RNA splicing; Protein kinase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; EC 2.7.11.22; Protein kinase, CMGC; Kinase, protein; EC 2.7.11.23; CMGC group; CDK family; CRK7 subfamily; CDK/CRK7 subfamily. Chromosomal Location of Human Ortholog: 17q12. Cellular Component: nucleoplasm; nuclear cyclin-dependent protein kinase holoenzyme complex; nucleolus; nuclear speck; nucleus. Molecular Function: RNA polymerase subunit kinase activity; cyclin binding; protein binding; cyclin-dependent protein kinase activity; ATP binding; protein kinase activity. Biological Process: regulation of cell cycle; regulation of MAP kinase activity; RNA splicing; protein amino acid autophosphorylation; mRNA processing

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage