ARNT2 Antibody | MyBioSource MBS2525431 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ARNT2 Antibody

catalog :

MBS2525431

quantity :

0.06 mL

price :

195 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

HEK-293 cells were subjected to SDS -PAGE fo11owed by western blot with ARNT2 antibody at dilution of 1:300

image 2 :

Immunohistochemical of paraffin-embedded human gliomas using ARNT2 antibody at dilution of 1:100 (under l0xlens)

product information

catalog number :

MBS2525431

products type :

Antibody

products full name :

ARNT2 Antibody

products short name :

[ARNT2]

products name syn :

[KIAA0307; bHLHe1]

other names :

[aryl hydrocarbon receptor nuclear translocator 2; Aryl hydrocarbon receptor nuclear translocator 2; aryl hydrocarbon receptor nuclear translocator 2; ARNT protein 2; class E basic helix-loop-helix protein 1; aryl-hydrocarbon receptor nuclear translocator 2; Class E basic helix-loop-helix protein 1; bHLHe1]

products gene name :

[ARNT2]

other gene names :

[ARNT2; ARNT2; WEDAS; bHLHe1; BHLHE1; KIAA0307; ARNT protein 2; bHLHe1]

uniprot entry name :

ARNT2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

717

purity :

Antigen affinity purification

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:200-1:2000. IHC: 1:50-1:200

image1 heading :

Testing Data

image2 heading :

Immunohistochemical

other info1 :

Immunogen: Fusion protein of ARNT2. Calculated Molecular Weight: 716aa; 79kd. Observed Molecular Weight: 80-85kd

other info2 :

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8078 / sc-5581

products description :

Aryl-hydrocarbon receptor nuclear translocator 2(ARNT2), is a member of the basic-helix-Ioop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. It specifically recognizes the xenobiotic response element(XRE). ARNT2 plays an important role in normal glucose handling in pancreatic beta cell function in humans and mice. ARNT2 proteins are dimericpartners for other PAS proteins such as HIF and SIM. ARNT2 and the other ARNT family members, e.g., ARNT, hypoxin inducible factor la (HIFIa), HIF2a, and aryl hydrocarbon receptor (AhR), are thought to function as heterodimers, and regulate the expression, and thereby the function, of rnany genes. Under hypoxic conditions, it complexes with hypoxia-inducible factor lalpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. Modulation of ARNT2 in pancreatic beta cells affects glucose stimulated insulin secretion (GSIS). This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human ARNT2.

ncbi gi num :

68303555

ncbi acc num :

NP_055677.3

ncbi gb acc num :

NM_014862.3

ncbi pathways :

Pathways In Cancer (83105); Renal Cell Carcinoma Pathway (83107); Renal Cell Carcinoma Pathway (519); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

ncbi summary :

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013]

uniprot summary :

ARNT2: Specifically recognizes the xenobiotic response element (XRE). 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; Apoptosis; DNA-binding. Chromosomal Location of Human Ortholog: 15q24. Cellular Component: transcription factor complex; cytoplasm; nucleus. Molecular Function: signal transducer activity; DNA binding; aryl hydrocarbon receptor binding; protein heterodimerization activity; transcription factor activity. Biological Process: central nervous system development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; in utero embryonic development; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; brain development; signal transduction; response to estradiol stimulus; negative regulation of apoptosis. Disease: Webb-dattani Syndrome

size1 :

0.06 mL

price1 :

195 USD

size2 :

0.12 mL

price2 :

270

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage