GATA2 Antibody | MyBioSource MBS2525270 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GATA2 Antibody

catalog :

MBS2525270

quantity :

0.06 mL

price :

195 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of Hela cells, using GATA2 Polyclonal Antibody at dilution of 1:1000

image 2 :

Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using GATA2 Polyclonal Antibody at dilution of 1:50

image 3 :

Immunofluorescent analysis of HepG2 cells using GATA2 Polyclonal Antibody at dilution of 1:100

product information

catalog number :

MBS2525270

products type :

Antibody

products full name :

GATA2 Antibody

products short name :

[GATA2]

products name syn :

[GATA binding protein 2, GATA2, NFE1B]

other names :

[GATA2 protein; Endothelial transcription factor GATA-2; endothelial transcription factor GATA-2; GATA binding protein 2; GATA-binding protein 2]

products gene name :

[GATA2]

other gene names :

[GATA2; GATA2; DCML; IMD21; NFE1B; MONOMAC]

uniprot entry name :

GATA2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

purity :

Affinity purification

form :

PBS with 0.1% sodium azide, 50% glycerol, pH7.3

storage stability :

Store at -20 degree C, Avoid freeze / thaw cycles

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

WB 1:500-1:3000, IHC 1:20-1:200, IF 1:20-1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunofluorescent (IF)

other info1 :

Immunogen: Fusion protein of human GATA2

other info2 :

Note: Centrifuge before opening to ensure complete recovery of vial contents.

products description :

GATA2 is a member of GATA family of transcription factors that contains zinc fingers in DNA binding domain. GATA2 acts as a transcriptinal activator that regulates endothelin-1 expression in endothelial cells. Together with GATA3, GATA2 regulates adipocyte differentiation through molecular control of the preadpocyte-adipocyte transition. It also affect the activity of Rho inhibitor p190RhoGAP that controls capillary network activity of Rho inhibitor p190RhoGAP that controls capillary network formation in vitro and retinal angiogenesis in vivo.

ncbi gi num :

30410878

ncbi acc num :

AAH51272.1

uniprot acc num :

P23769

ncbi mol weight :

Calculated MW: 50kDa. Observed MW: 50-66kDa

ncbi pathways :

Adipogenesis Pathway (198832); Factors Involved In Megakaryocyte Development And Platelet Production Pathway (187196); HIF-1-alpha Transcription Factor Network Pathway (138045); Hemostasis Pathway (106028); IL-3 Signaling Pathway (198881); Regulation Of Androgen Receptor Activity Pathway (138027); SIDS Susceptibility Pathways (198901); Signaling Events Mediated By HDAC Class I Pathway (137997); Signaling Events Mediated By HDAC Class II Pathway (138062)

ncbi summary :

This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

uniprot summary :

GATA2: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5 -AGATAG-3 . Endothelial cells. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor. Chromosomal Location of Human Ortholog: 3q21.3. Cellular Component: nucleoplasm; protein complex. Molecular Function: protein binding; zinc ion binding; chromatin binding; transcription factor activity; transcription factor binding. Biological Process: inner ear morphogenesis; embryonic placenta development; transcription, DNA-dependent; somatic stem cell maintenance; positive regulation of erythrocyte differentiation; cell maturation; regulation of histone acetylation; negative regulation of transcription from RNA polymerase II promoter; cell fate determination; negative regulation of fat cell differentiation; phagocytosis; positive regulation of angiogenesis; cell differentiation in hindbrain; negative regulation of macrophage differentiation; pituitary gland development; homeostasis of number of cells within a tissue; ventral spinal cord interneuron differentiation; commitment of a neuronal cell to a specific type of neuron in the forebrain; positive regulation of phagocytosis; negative regulation of Notch signaling pathway; positive regulation of megakaryocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; urogenital system development; central nervous system neuron development. Disease: Lymphedema, Primary, With Myelodysplasia; Immunodeficiency 21; Myelodysplastic Syndrome

size1 :

0.06 mL

price1 :

195 USD

size2 :

0.12 mL

price2 :

270

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage