product summary
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company name :
MyBioSource
product type :
antibody
product name :
FLI1 Polyclonal Antibody
catalog :
MBS2525014
quantity :
0.02 mL
price :
110 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, enzyme immunoassay
more info or order :
image
image 1 :
Western Blot analysis of Hela cell using FLI1 Polyclonal Antibody at dilution of 1:200
product information
catalog number :
MBS2525014
products type :
Antibody
products full name :
FLI1 Polyclonal Antibody
products short name :
[FLI1]
products name syn :
[EWSR2; SIC-1]
other names :
[Friend leukemia integration 1 transcription factor isoform 4; Friend leukemia integration 1 transcription factor; Friend leukemia integration 1 transcription factor; Ewing sarcoma breakpoint region 2; Friend leukemia virus integration 1; transcription factor ERGB; Fli-1 proto-oncogene, ETS transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB]
products gene name :
[FLI1]
other gene names :
[FLI1; FLI1; EWSR2; SIC-1]
uniprot entry name :
FLI1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse.
sequence length :
259
purity :
Affinity purification
concentration :
0.2mg/mL
storage stability :
Store at -20°C. Avoid freeze/thaw cycles.
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
WB: 1:200-1:1000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant protein of human FLI1. Calculated MW: 51kDa
other info2 :
Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
products categories :
Cancer; Cell biology; Epigenetics
products description :
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11; 22)(q24; q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4; 11)(q21; q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
ncbi gi num :
401871078
ncbi acc num :
BC001670
ncbi gb acc num :
NM_001271012.1
ncbi pathways :
Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)
ncbi summary :
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
uniprot summary :
FLI1: Sequence-specific transcriptional activator. Recognizes the DNA sequence 5 -C[CA]GGAAGT-3 . Defects in FLI1 are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1. Belongs to the ETS family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Oncoprotein; Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 11q24.1-q24.3. Cellular Component: nucleus. Molecular Function: DNA binding; chromatin binding; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; blood circulation; hemostasis; positive regulation of transcription from RNA polymerase II promoter; cell differentiation
size1 :
0.02 mL
price1 :
110 USD
size2 :
0.06 mL
price2 :
150
size3 :
0.12 mL
price3 :
225
size4 :
0.2 mL
price4 :
360
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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