ATP6AP2 Polyclonal Antibody | MyBioSource MBS2524653 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ATP6AP2 Polyclonal Antibody

catalog :

MBS2524653

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ATP6AP2 Polyclonal Antibody at dilution 1:50

product information

catalog number :

MBS2524653

products type :

Antibody

products full name :

ATP6AP2 Polyclonal Antibody

products short name :

[ATP6AP2]

products name syn :

[M8-9; MRXE; XMRE; HT028; ELDF10; ATP6IP2; MSTP009; APT6M8-9; ATP6M8-9]

other names :

[ATP6AP2 protein; Renin receptor; renin receptor; ATPase H(+)-transporting lysosomal-interacting protein 2; ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8-9; ATPase, H+ transporting, lysosomal interacting protein 2; ER-localized type I transmembrane adaptor; N14F; V-ATPase M8.9 subunit; embryonic liver differentiation factor 10; prorenin receptor; renin/prorenin receptor; vacuolar ATP synthase membrane sector-associated protein M8-9; vacuolar proton ATP synthase membrane sector associated protein M8-9; ATPase, H+ transporting, lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; ER-localized type I transmembrane adaptor; Embryonic liver differentiation factor 10; N14F; Renin/prorenin receptor; Vacuolar ATP synthase membrane sector-associated protein M8-9; ATP6M8-9; V-ATPase M8.9 subunit]

products gene name :

[ATP6AP2]

other gene names :

[ATP6AP2; ATP6AP2; PRR; M8-9; MRXE; RENR; XMRE; XPDS; HT028; MRXSH; ELDF10; ATP6IP2; MSTP009; APT6M8-9; ATP6M8-9; ATP6IP2; CAPER; ELDF10; ATP6M8-9; V-ATPase M8.9 subunit]

uniprot entry name :

RENR_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

purity :

Affinity purification

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

app notes :

IHC: 1:25-1:100

image1 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Recombinant protein of human ATP6AP2

other info2 :

Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3

products description :

This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases.

ncbi gi num :

14714522

ncbi acc num :

AAH10395.1

ncbi pathways :

ACE Inhibitor Pathway (198763); Metabolism Of Angiotensinogen To Angiotensins Pathway (685555); Metabolism Of Proteins Pathway (106230); Oxidative Phosphorylation Pathway (198870); Peptide Hormone Metabolism Pathway (771603); Wnt Signaling Network Pathway (137962)

ncbi summary :

uniprot summary :

ATP6AP2: Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). Defects in ATP6AP2 are a cause of mental retardation X- linked with epilepsy (MRXE). MRXE is a syndromic mental retardation. Patients manifest mild to moderate mental retardation associated with epilepsy, delays in motor milestones and speech acquisition in infancy. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: Xp11.4. Cellular Component: neuron projection; integral to membrane; plasma membrane; external side of plasma membrane. Molecular Function: protein binding; enzyme binding; receptor activity; aspartic-type endopeptidase activity. Biological Process: positive regulation of transforming growth factor-beta1 production; rostrocaudal neural tube patterning; cellular protein metabolic process; regulation of MAPKKK cascade; proteolysis; angiotensin maturation; positive regulation of Wnt receptor signaling pathway; eye pigmentation. Disease: Mental Retardation, X-linked, Syndromic, Hedera Type; Parkinsonism With Spasticity, X-linked

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage