product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
CRLS1 Antibody
catalog :
MBS2524265
quantity :
0.06 mL
price :
195 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2524265
products type :
Antibody
products full name :
CRLS1 Antibody
products short name :
CRLS1
products name syn :
C20orf155; CLS1; GCD10; dJ967N21.6
other names :
CRLS1 protein; Cardiolipin synthase; cardiolipin synthase; cardiolipin synthase 1; Protein GCD10 homolog
products gene name :
CRLS1
other gene names :
CRLS1; CRLS1; CLS; CLS1; GCD10; C20orf155; dJ967N21.6; C20orf155; CLS1; CLS
uniprot entry name :
CRLS1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
205
purity :
Antigen affinity purification
concentration :
300 ug/ml
storage stability :
Store at -20 degree C. Avoid freeze / thaw cycles
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:200-1:1000. IHC: 1:20-1:200
other info1 :
Immunogen: Peptide of CRLS1. Calculated Molecular Weight: 301aa; 32kd. Observed Molecular Weight: 50 kDa
other info2 :
Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
products description :
Cardiolipin (CL) is a mitochondrial specific double negatively charged phospholipid which is intricately involved in regulating bioenergetics efficiency. In eukaryotes, GL is synthesized by cardiolipin synthase (CRLSI or CLS1) which catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form CL and glycerol. Recently it has been reported that transgenic expression of CRLS 1 Accelerates cardiolipin remodeling, improves mitochondrial function, modulates mitochondrial sigl1!l.ling, and attenuates mitochondrial dysfunction during diabetes, thereby identifying CRLS 1 as a novel therapeutic target to attenuate mitochondrial dysfunction in diabetic myocardium.
ncbi gi num :
46362465
ncbi acc num :
AAH69010.1
uniprot acc num :
Q6NTG3
ncbi pathways :
Acyl Chain Remodelling Of PG Pathway (645328); Glycerophospholipid Biosynthesis Pathway (645313); Glycerophospholipid Metabolism Pathway (82989); Glycerophospholipid Metabolism Pathway (364); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Phospholipid Metabolism Pathway (645312); Synthesis Of CL Pathway (645329)
uniprot summary :
CRLS1: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Lipid Metabolism - glycerophospholipid; Transferase; Mitochondrial; EC 2.7.8.-; Membrane protein, integral. Chromosomal Location of Human Ortholog: 20p13-p12.3. Cellular Component: mitochondrial inner membrane; integral to membrane. Molecular Function: phosphotransferase activity, for other substituted phosphate groups. Biological Process: cardiolipin biosynthetic process; phospholipid metabolic process; glycerophospholipid biosynthetic process
size1 :
0.06 mL
price1 :
195 USD
size2 :
0.12 mL
price2 :
270
size3 :
0.2 mL
price3 :
435
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!