ALPP Polyclonal Antibody | MyBioSource MBS2524098 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ALPP Polyclonal Antibody

catalog :

MBS2524098

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of HepG2 cell and Human placenta tissue using ALPP Polyclonal Antibody at dilution of 1:1450

image 2 :

Immunohistochemistry of paraffin-embedded Human lung cancer using ALPP Polyclonal Antibody at dilution of 1:50

image 3 :

Immunohistochemistry of paraffin-embedded Human colon cancer using ALPP Polyclonal Antibody at dilution of 1:50

product information

catalog number :

MBS2524098

products type :

Antibody

products full name :

ALPP Polyclonal Antibody

products short name :

[ALPP]

products name syn :

[ALP; PALP; PLAP; PLAP-1]

other names :

[alkaline phosphatase, placental type preproprotein; Alkaline phosphatase, placental type; alkaline phosphatase, placental type; alkaline phosphatase Regan isozyme; alkaline phosphomonoesterase; glycerophosphatase; placental alkaline phosphatase 1; alkaline phosphatase, placental; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1]

products gene name :

[ALPP]

other gene names :

[ALPP; ALPP; ALP; PALP; PLAP; PLAP-1; PLAP; PLAP-1]

uniprot entry name :

PPB1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

535

purity :

Affinity purification

form :

PBS with 0.05% sodium azide, 50% glycerolm pH 7.3

concentration :

0.6mg/mL

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:1000-1:5000. IHC: 1:50-1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Recombinant protein of human ALPP

products categories :

Cell biology

products description :

Background/Introduction: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.

ncbi gi num :

94721246

ncbi acc num :

NP_001623.3

ncbi gb acc num :

NM_001632.4

uniprot acc num :

BC009647

ncbi pathways :

Folate Biosynthesis Pathway (83018); Folate Biosynthesis Pathway (404); Metabolic Pathways (132956); Pyridoxal 5'-phosphate Salvage Pathway (142237)

ncbi summary :

The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]

uniprot summary :

ALPP: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3 untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]. Protein type: Cell surface; Cofactor and Vitamin Metabolism - folate biosynthesis; Motility/polarity/chemotaxis; Phosphatase (non-protein); Membrane protein, GPI anchor; Membrane protein, integral; EC 3.1.3.1. Chromosomal Location of Human Ortholog: 2q37. Cellular Component: cell surface; integral to membrane; plasma membrane. Molecular Function: zinc ion binding; alkaline phosphatase activity; magnesium ion binding. Biological Process: dephosphorylation

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage