catalog number :
MBS2523947
products full name :
AMH Antibody
products short name :
AMH
products name syn :
MIF; MIS
other names :
Amh protein, partial; Muellerian-inhibiting factor; muellerian-inhibiting factor; Mullerian inhibiting substance; anti-Muellerian hormone; muellerian-inhibiting substance; anti-Mullerian hormone; Anti-Muellerian hormone; AMH; Muellerian-inhibiting substance; MIS
other gene names :
Amh; Amh; MIS; AMH; MIS
uniprot entry name :
MIS_MOUSE
reactivity :
Human, Mouse
purity :
Antigen affinity purified
storage stability :
Store at -20 degree C. Avoid freeze / thaw cycles
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:200-1:1000. IHC: 1:10-1:100
other info1 :
Immunogen: Fusion protein of AMH. Calculated Molecular Weight: 59kd. Observed Molecular Weight: 65kd-70kd
other info2 :
Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
products description :
Anti-Mullerian hormone (AMH), also called Mullerian-inhibiting substance (MIS), is a hormone that is best known for its production by fetal testes in mammals and as the inhibitor of Mullerian duct development in males. AMH is also expressed in granulosa cells of pre antral and small antral follicles in the ovary. More recently, AMH has been studied for its role in ovarian folliculogenesis and as a potential marker of ovarian reserve.This antibody is specific to AMH.
ncbi acc num :
AAI50478.1
ncbi pathways :
BMP Signaling Pathway (1084868); BMP Signaling Pathway (1108218); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Hippo Signaling Pathway (749786); Hippo Signaling Pathway (750388); TGF-beta Signaling Pathway (83261); TGF-beta Signaling Pathway (475); CAMP Signaling Pathway (1017641); CAMP Signaling Pathway (1019520)
ncbi summary :
This gene is a member of the transforming growth factor-beta superfamily of growth and differentiation factors. The encoded protein is produced in fetal Sertoli cells during male gonadal differentiation. The protein binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in developing male embryos. In humans, some mutations in this gene are associated with persistent Mullerian duct syndrome (PMDS). [provided by RefSeq, Apr 2013]
uniprot summary :
AMH: This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. Defects in AMH are the cause of persistent Muellerian duct syndrome type 1 (PMDS1). PMDS1 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males. Belongs to the TGF-beta family. Protein type: Secreted, signal peptide; Secreted. Cellular Component: extracellular space; cytoplasm. Molecular Function: hormone activity; transforming growth factor beta receptor binding; receptor binding. Biological Process: Mullerian duct regression; cell-cell signaling; preantral ovarian follicle growth; urogenital system development; activation of NF-kappaB transcription factor