LAMA1 Polyclonal Antibody | MyBioSource MBS2523824 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LAMA1 Polyclonal Antibody

catalog :

MBS2523824

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded Human brain tissue using LAMA1 Polyclonal Antibody at dilution of 1:70

image 2 :

Immunohistochemistry of paraffin-embedded Human colon cancer using LAMA1 Polyclonal Antibody at dilution of 1:70

product information

catalog number :

MBS2523824

products type :

Antibody

products full name :

LAMA1 Polyclonal Antibody

products short name :

[LAMA1]

products name syn :

[LAMA, S-LAM-alpha]

other names :

[laminin subunit alpha-1; Laminin subunit alpha-1; laminin subunit alpha-1; S-LAM alpha; S-laminin subunit alpha; laminin A chain; laminin-3 subunit alpha; laminin, alpha 1; Laminin A chain; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-laminin subunit alpha; S-LAM alpha]

products gene name :

[LAMA1]

other gene names :

[LAMA1; LAMA1; LAMA; PTBHS; S-LAM-alpha; LAMA; S-LAM alpha]

uniprot entry name :

LAMA1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

3075

purity :

Affinity purification

concentration :

0.7mg/mL

storage stability :

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

app notes :

IHC: 1:50-1:200

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

products description :

Background/Introduction: Laminin subunit alpha-1?is a?protein?that in humans is encoded by the?LAMA1?gene. Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121 or S-laminin). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

ncbi gi num :

38788416

ncbi acc num :

NP_005550.2

ncbi gb acc num :

NM_005559.3

ncbi mol weight :

337,084 Da

ncbi pathways :

Alpha6-Beta4 Integrin Signaling Pathway (198807); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); ECM Proteoglycans Pathway (833812); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795)

ncbi summary :

This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]

uniprot summary :

LAMA1: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Extracellular matrix. Chromosomal Location of Human Ortholog: 18p11.3. Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; laminin-1 complex; laminin-3 complex; extracellular region; basement membrane; intercellular junction. Molecular Function: protein binding; extracellular matrix structural constituent; glycosphingolipid binding; receptor binding. Biological Process: regulation of cell adhesion; axon guidance; extracellular matrix organization and biogenesis; cell surface receptor linked signal transduction; regulation of embryonic development; morphogenesis of an epithelial sheet; establishment of epithelial cell polarity; cell adhesion; regulation of cell migration. Disease: Poretti-boltshauser Syndrome

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage