catalog number :
MBS2523795
products full name :
RMDN3 Polyclonal Antibody
products short name :
[RMDN3]
products name syn :
[RMD3; RMD-3; FAM82C; FAM82A2; ptpip51]
other names :
[regulator of microtubule dynamics protein 3; Regulator of microtubule dynamics protein 3; regulator of microtubule dynamics protein 3; TCPTP-interacting protein 51; cerebral protein 10; family with sequence similarity 82, member A2; family with sequence similarity 82, member C; microtubule-associated protein; protein tyrosine phosphatase-interacting protein 51; regulator of microtubule dynamics 3; Cerebral protein 10; Protein FAM82A2; Protein FAM82C; Protein tyrosine phosphatase-interacting protein 51; TCPTP-interacting protein 51]
products gene name :
[RMDN3]
other gene names :
[RMDN3; RMDN3; RMD3; RMD-3; FAM82C; FAM82A2; ptpip51; FAM82A2; FAM82C; PTPIP51; RMD-3; hRMD-3]
uniprot entry name :
RMD3_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Affinity purification
storage stability :
Store at -20°C. Avoid freeze / thaw cycles.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:200-1:1000. IHC: 1:25-1:100
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Recombinant protein of human RMDN3. Calculated MW: 52kDa
other info2 :
Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
products categories :
Cell biology
products description :
Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression.
ncbi gb acc num :
NM_001304802.1
uniprot summary :
FAM82A2: a single-pass membrane protein in the mitochondrial membrane. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system. Induced by EGF, TGF-beta, retinoic acid-and 1,25-Dihydroxyvitamin D(3). Two alternatively spliced human isoforms may be produced. Protein type: Apoptosis; Mitochondrial; Membrane protein, integral. Chromosomal Location of Human Ortholog: 15q15.1. Cellular Component: spindle pole; microtubule; mitochondrial outer membrane; mitochondrion; integral to membrane; nucleus. Molecular Function: protein binding. Biological Process: cellular calcium ion homeostasis; apoptosis; cell differentiation