TXNRD2 Antibody | MyBioSource MBS2523012 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TXNRD2 Antibody

catalog :

MBS2523012

quantity :

0.06 mL

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts ofvarious cell lines with TXNRD2 Polyclonal Antibody

image 2 :

Immunohistochemistry of paraffin-embedded human liver cancer with TXNRD2 Polyclonal Antibody

image 3 :

Immunohistochemistry of paraffin-embedded human liver injury with TXNRD2 Polyclonal Antibody

product information

catalog number :

MBS2523012

products type :

Antibody

products full name :

TXNRD2 Antibody

products short name :

[TXNRD2]

products name syn :

[SELZ;TR;TR-BETA;TR3;TRXR2]

other names :

[thioredoxin reductase 2, mitochondrial isoform 2; Thioredoxin reductase 2, mitochondrial; thioredoxin reductase 2, mitochondrial; selenoprotein Z; thioredoxin reductase 3; thioredoxin reductase TR3; thioredoxin reductase beta; thioredoxin reductase 2; Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3]

products gene name :

[TXNRD2]

other gene names :

[TXNRD2; TXNRD2; TR; TR3; SELZ; TRXR2; TR-BETA; KIAA1652; TRXR2; SelZ]

uniprot entry name :

TRXR2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

338

purity :

Affinity purification

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB 1:500 - 1:2000. IHC 1:50 - 1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Recombinant protein of human TXNRD2. Calculated MW: 30kDa/46kDa/53kDa/56kDa. Observed MW: 56kDa. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

other info2 :

Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-365714 / sc-166259

products description :

The protein encoded by this gene belongs to the pyridine nucleotidedisulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conservedstem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stopsignal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the Cterminal Sec residue, have been found for this gene.

ncbi gi num :

542029077

ncbi acc num :

NP_001269441.1

ncbi gb acc num :

NM_001282512.1

ncbi pathways :

Cellular Responses To Stress Pathway (645258); Detoxification Of Reactive Oxygen Species Pathway (1127552); Oxidative Stress Pathway (198916); Pyrimidine Metabolism Pathway (82946); Pyrimidine Metabolism Pathway (309); Selenium Pathway (219762); Selenium Pathway (198359); Selenium Metabolism And Selenoproteins Pathway (198846); Selenium Pathway (198825); Selenocompound Metabolism Pathway (82969)

ncbi summary :

This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]

uniprot summary :

TXNRD2: Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; EC 1.8.1.9; Nucleotide Metabolism - pyrimidine; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 22q11.21. Cellular Component: mitochondrion; mitochondrial matrix. Molecular Function: protein binding; mercury (II) reductase activity; thioredoxin-disulfide reductase activity; FAD binding; mercury ion binding; NADP binding. Biological Process: response to reactive oxygen species; response to oxygen radical; cell redox homeostasis; detoxification of mercury ion

size1 :

0.06 mL

price1 :

150 USD

size2 :

0.12 mL

price2 :

225

size3 :

0.2 mL

price3 :

360

more info or order :

MyBioSource product webpage