TXN Polyclonal Antibody | MyBioSource MBS2522962 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TXN Polyclonal Antibody

catalog :

MBS2522962

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded Human liver cancer using TXN Polyclonal Antibody at dilution of 1:40

image 2 :

Immunohistochemistry of paraffin-embedded Human lung cancer using TXN Polyclonal Antibody at dilution of 1:40

product information

catalog number :

MBS2522962

products type :

Antibody

products full name :

TXN Polyclonal Antibody

products short name :

[TXN]

products name syn :

[TRX; TRDX; TRX1]

other names :

[thioredoxin isoform 2; Thioredoxin; thioredoxin; ADF; ATL-derived factor; SASP; TXN delta 3; surface-associated sulphydryl protein; thioredoxin delta 3; thioredoxin; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP]

products gene name :

[TXN]

other gene names :

[TXN; TXN; TRX; TRDX; TRX1; TRDX; TRX; TRX1; Trx; ADF; SASP]

uniprot entry name :

THIO_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Rat

sequence length :

purity :

Affinity purification

concentration :

0.3mg/mL

storage stability :

Store at -20 degree C. Avoid freeze/thaw cycles.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:1000-1:5000. IHC: 1:50-1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

products categories :

Epigenetics

products description :

Background: The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity.

ncbi gi num :

349732256

ncbi acc num :

NP_003320

ncbi gb acc num :

NM_001244938.1

uniprot acc num :

P10599

ncbi pathways :

Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); Detoxification Of Reactive Oxygen Species Pathway (1127552); Folic Acid Network Pathway (920880); Folic Acid Network Pathway (219799); Folic Acid Network Pathway (198383); Immune System Pathway (106386); Inflammasomes Pathway (366166); Innate Immune System Pathway (106387); Metabolism Pathway (477135)

ncbi summary :

The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

uniprot summary :

TXN: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA- binding activity in a redox-dependent manner. Up-regulated by ionizing radiation. Belongs to the thioredoxin family. Protein type: Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 9q31. Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus; cytosol. Molecular Function: protein binding; protein disulfide oxidoreductase activity; peptide disulfide oxidoreductase activity. Biological Process: negative regulation of protein export from nucleus; transcription, DNA-dependent; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; activation of protein kinase B; negative regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of peptidyl-serine phosphorylation; glycerol ether metabolic process; positive regulation of protein kinase B signaling cascade; cell proliferation; response to reactive oxygen species; response to radiation; cell-cell signaling; cell redox homeostasis; innate immune response; regulation of protein import into nucleus, translocation; cell motility; positive regulation of DNA binding

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage