CDK4 Polyclonal Antibody | MyBioSource MBS2522905 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CDK4 Polyclonal Antibody

catalog :

MBS2522905

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of Hela and 293T cell using CDK4 Polyclonal Antibody at dilution of 1:450

image 2 :

Immunohistochemistry of paraffin-embedded Human thyroid cancer using CDK4 Polyclonal Antibody at dilution of 1:10

product information

catalog number :

MBS2522905

products type :

Antibody

products full name :

CDK4 Polyclonal Antibody

products short name :

[CDK4]

products name syn :

[CMM3, PSK-J3]

other names :

[cyclin-dependent kinase 4; Cyclin-dependent kinase 4; cyclin-dependent kinase 4; cell division protein kinase 4; cyclin-dependent kinase 4; Cell division protein kinase 4; PSK-J3]

products gene name :

[CDK4]

other gene names :

[CDK4; CDK4; CMM3; PSK-J3]

uniprot entry name :

CDK4_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

303

purity :

Affinity purification

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500-1:2000. IHC: 1:10-1:50

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Recombinant protein of human CDK4. Calculated MW: 34kDa

other info2 :

Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3

products categories :

Cancer; Cell biology; Epigenetics

products description :

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

ncbi gi num :

4502735

ncbi acc num :

BC003644

ncbi gb acc num :

NM_000075.3

uniprot acc num :

P11802

ncbi pathways :

ATF-2 Transcription Factor Network Pathway (138006); B Cell Receptor Signaling Pathway (198909); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463)

ncbi summary :

uniprot summary :

CDK4: a protein kinase of the CDK family that is important for cell cycle G1 phase progression. Its activity is restricted to the G1-S phase. Controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). Phosphorylates the retinoblastoma gene product (Rb). Point mutations found in somatic and familial melanoma. Amplified in sarcomas, glioma and lymphoma. Amplified, methylated or deleted in head and neck squamous cell carcinoma. Overexpression drives epithelial tumors in mice. Disruption makes mice resistant to cancer. Inhibitor: PD332991. Protein type: Protein kinase, Ser/Thr (non-receptor); Cell cycle regulation; Protein kinase, CMGC; Kinase, protein; EC 2.7.11.22; CMGC group; CDK family; CDK4 subfamily; CDK/CDK4 subfamily. Chromosomal Location of Human Ortholog: 12q14. Cellular Component: nucleoplasm; transcription factor complex; nuclear membrane; tight junction; perinuclear region of cytoplasm; nucleolus; cyclin-dependent protein kinase holoenzyme complex; chromatin; nucleus; cytosol. Molecular Function: cyclin binding; protein binding; cyclin-dependent protein kinase activity; protein complex binding; cyclin-dependent protein kinase regulator activity; ATP binding. Biological Process: circadian rhythm; lens development in camera-type eye; response to drug; establishment and/or maintenance of chromatin architecture; organ regeneration; positive regulation of translation; positive regulation of cell size; positive regulation of apoptosis; response to toxin; response to testosterone stimulus; signal transduction; protein amino acid phosphorylation; positive regulation of fibroblast proliferation; response to hyperoxia; regulation of gene expression; cell division; response to lead ion; positive regulation of cell proliferation; mitotic cell cycle; regulation of protein kinase activity; G1/S transition of mitotic cell cycle. Disease: Melanoma, Cutaneous Malignant, Susceptibility To, 3

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage