catalog number :
MBS2522738
products full name :
CXCL14 Polyclonal Antibody
products short name :
[CXCL14]
products name syn :
[KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14]
other names :
[C-X-C motif chemokine 14; C-X-C motif chemokine 14; C-X-C motif chemokine 14; CXC chemokine in breast and kidney; MIP-2 gamma; bolekine; chemokine BRAK; small inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK); small-inducible cytokine B14; tumor-suppressing chemokine; chemokine (C-X-C motif) ligand 14; Chemokine BRAK; MIP-2G; Small-inducible cytokine B14]
products gene name :
[CXCL14]
other gene names :
[CXCL14; CXCL14; KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14; MIP2G; NJAC; SCYB14]
uniprot entry name :
CXL14_HUMAN
purity :
Affinity purification
storage stability :
Store at -20°C. Avoid freeze / thaw cycles.
tested application :
ELISA (EIA), Immunohistochemistry (IHC)
app notes :
IHC: 1:50-1:200
image1 heading :
Immunohistochemistry (IHC)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Recombinant protein of human CXCL14
other info2 :
Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
products categories :
Epigenetics
products description :
This gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation.
ncbi acc num :
NP_004878.2
ncbi gb acc num :
NM_004887.4
uniprot acc num :
BC003513
ncbi pathways :
Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Senescence And Autophagy Pathway (198780)
ncbi summary :
This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]
uniprot summary :
CXCL14: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. Belongs to the intercrine alpha (chemokine CxC) family. Protein type: Secreted, signal peptide; Chemokine; Motility/polarity/chemotaxis; Secreted. Chromosomal Location of Human Ortholog: 5q31. Cellular Component: Golgi apparatus; extracellular space. Molecular Function: chemokine activity. Biological Process: cell-cell signaling; immune response; negative regulation of myoblast differentiation; signal transduction; chemotaxis; inner ear development