Beta Arrestin 2 Antibody | MyBioSource MBS2522670 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Beta Arrestin 2 Antibody

catalog :

MBS2522670

quantity :

0.06 mL

price :

195 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

RAW264.7 cells were subjected toSDS PAGE followed by western blotwith Beta Arrestin 2 Antibody atdilution of 1:2000

image 2 :

If result of Mouse Retina using anti-ARRB2 antibody.

image 3 :

Immunohistochemistry of paraffin-embedded human tonsil tissue slide using Beta Arrestin 2 Antibody at dilution of 1:200 .

product information

catalog number :

MBS2522670

products type :

Antibody

products full name :

Beta Arrestin 2 Antibody

products short name :

[Beta Arrestin 2]

products name syn :

[ARB2, ARR2, ARRB2, Arrestin beta 2, arrestin, beta 2, BARR2, Beta arrestin 2, DKFZp686L0365]

other names :

[beta-arrestin-2 isoform 2; Beta-arrestin-2; beta-arrestin-2; arrestin 3; arrestin beta-2; arrestin, beta 2; Arrestin beta-2]

other gene names :

[ARRB2; ARRB2; ARB2; ARR2; BARR2; ARB2; ARR2]

uniprot entry name :

ARRB2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

H, M, Xenopus

sequence length :

394

purity :

Antigen affinity purification

storage stability :

Store at -20°C. Avoid freeze / thaw cycles

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

WB 1:1000-1:4000. IHC 1:50-1:500. IF 1:20-1:200

image1 heading :

Testing Data

image2 heading :

Testing Data (TD)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Fusion protein of Beta Arrestin 2. Calculated MW: 46kd. Observed MW: 50kd

other info2 :

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

products description :

Beta Arrestin 2 is a member of arrestin/beta-arrestin protein family,which are expressed at high levels in the central nervous system (CNS)and play a critical role in the regulation of G-protein coupled receptors(GPCRs) including MOR. Beta Arrestin 2 is an adaptor protein that isimportant for the regulation of receptors belonging to both dopaminergicand opioid systems. Besides the brain, a cDNA for arrestin beta 2 wasisolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptor

ncbi gi num :

39812055

ncbi acc num :

NP_945355.1

ncbi gb acc num :

NM_199004.1

uniprot acc num :

BC007427

ncbi pathways :

ALK1 Signaling Events Pathway (137968); Activated NOTCH1 Transmits Signal To The Nucleus Pathway (576270); Activation Of SMO Pathway (1127544); Arf6 Signaling Events Pathway (138034); Atypical NF-kappaB Pathway (137946); CXCR4-mediated Signaling Events Pathway (137910); Calcium Regulation In The Cardiac Cell Pathway (198906); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Corticotropin-releasing Hormone Pathway (920957)

ncbi summary :

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

uniprot summary :

ARRB2: a member of the arrestin/beta-arrestin protein family. These proteins participate in agonist-mediated desensitization of G-protein-coupled receptors. Acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Expressed at high levels in the CNS and peripheral blood leukocytes. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 17p13. Cellular Component: postsynaptic membrane; basolateral plasma membrane; endocytic vesicle; postsynaptic density; cytoplasm; plasma membrane; dendritic spine; coated pit; cytoplasmic vesicle; cytosol; nucleus. Molecular Function: angiotensin receptor binding; protein domain specific binding; protein kinase B binding; type 2A serotonin receptor binding; follicle stimulating hormone receptor binding; alpha-1B adrenergic receptor binding; alpha-1A adrenergic receptor binding; protein binding; enzyme binding; G-protein-coupled receptor binding; ubiquitin protein ligase binding; protein complex binding; mitogen-activated protein kinase binding; protein complex scaffold; type 1 angiotensin receptor binding; D1 dopamine receptor binding; receptor binding. Biological Process: transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; follicle-stimulating hormone signaling pathway; positive regulation of receptor internalization; protein ubiquitination; negative regulation of caspase activity; adult walking behavior; protein transport; transforming growth factor beta receptor signaling pathway; receptor internalization; negative regulation of interleukin-6 production; detection of temperature stimulus involved in sensory perception of pain; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; platelet activation; Notch signaling pathway; negative regulation of interleukin-12 production; negative regulation of natural killer cell mediated cytotoxicity; positive regulation of synaptic transmission, dopaminergic; negative regulation of interleukin-1 beta production; negative regulation of tumor necrosis factor production; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; G-protein coupled receptor internalization; positive regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; negative regulation of toll-like receptor signaling pathway; negative regulation of protein ubiquitination; brain development; blood coagulation; positive regulation of calcium ion transport

size1 :

0.06 mL

price1 :

195 USD

size2 :

0.12 mL

price2 :

270

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage