product summary
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company name :
MyBioSource
product type :
antibody
product name :
NKX2-5 Antibody
catalog :
MBS2522630
quantity :
0.06 mL
price :
150 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
more info or order :
image
image 1 :
Western blot analysis of extracts ofvarious cell lines with NKX2-5 Polyclonal Antibody
product information
catalog number :
MBS2522630
products type :
Antibody
products full name :
NKX2-5 Antibody
products short name :
[NKX2-5]
products name syn :
[CHNG5;CSX;CSX1;HLHS2;NKX2.5;NKX2E;NKX4-1;VSD3]
other names :
[Nkx2.5 protein; Nkx2.5 protein]
products gene name :
[NKX2-5]
other gene names :
[nkx2.5; Nkx2-5]
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse. Rat
purity :
Affinity purification
form :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
storage stability :
Store at -20°C. Avoid freeze/thaw cycles
tested application :
Western Blot (WB)
app notes :
WB 1:500 - 1:2000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant protein of human NKX2-5
other info2 :
Note: Centrifuge before opening to ensure complete recovery of vial contents.
products description :
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
ncbi gi num :
157278563
ncbi acc num :
NP_001098382.1
ncbi gb acc num :
NM_001104912.1
uniprot acc num :
P52952
ncbi mol weight :
Calculated MW: 11kDa/16kDa/34kDa. Observed MW: 37kDa
uniprot summary :
NKX2-5: Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4. Interacts with HIPK1 and HIPK2, but not HIPK3. Interacts with the C-terminal zinc finger of GATA4 through its homeobox domain. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with FBLIM1. Expressed only in the heart. Belongs to the NK-2 homeobox family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 5q34. Cellular Component: nucleus; transcription factor complex. Molecular Function: chromatin binding; DNA binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity; transcription factor binding. Biological Process: adult heart development; atrial cardiac muscle cell development; cardiac muscle cell differentiation; cardiac muscle morphogensis; cell differentiation; embryonic heart tube development; heart looping; heart morphogenesis; hemopoiesis; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; pharyngeal system development; positive regulation of cardioblast differentiation; positive regulation of cell proliferation; positive regulation of heart contraction; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; spleen development; thyroid gland development; vasculogenesis; ventricular cardiac muscle cell development. Disease: Atrial Septal Defect 7 With Or Without Atrioventricular Conduction Defects; Conotruncal Heart Malformations; Hypoplastic Left Heart Syndrome 2; Hypothyroidism, Congenital, Nongoitrous, 5; Tetralogy Of Fallot; Ventricular Septal Defect 3
size1 :
0.06 mL
price1 :
150 USD
size2 :
0.12 mL
price2 :
225
size3 :
0.2 mL
price3 :
360
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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