product summary
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company name :
MyBioSource
product type :
antibody
product name :
AKAP12 Polyclonal Antibody
catalog :
MBS2522529
quantity :
0.02 mL
price :
110 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
image
image 1 :
Immunohistochemistry of paraffin-embedded Human brain tissue using AKAP12 Polyclonal Antibody at dilution 1:40
image 2 :
Immunohistochemistry of paraffin-embedded Human lung cancer tissue using AKAP12 Polyclonal Antibody at dilution 1:40
product information
catalog number :
MBS2522529
products type :
Antibody
products full name :
AKAP12 Polyclonal Antibody
products short name :
[AKAP12]
products name syn :
[SSeCKS; AKAP250]
other names :
[A-kinase anchor protein 12 isoform 2; A-kinase anchor protein 12; A-kinase anchor protein 12; A-kinase anchor protein, 250kDa; AKAP 250; Src-Suppressed C Kinase Substrate; kinase scaffold protein gravin; myasthenia gravis autoantigen gravin; A kinase (PRKA) anchor protein 12; A-kinase anchor protein 250 kDa; AKAP 250; Gravin; Myasthenia gravis autoantigen]
products gene name :
[AKAP12]
other gene names :
[AKAP12; AKAP12; SSeCKS; AKAP250; AKAP250; AKAP-12; AKAP 250]
uniprot entry name :
AKA12_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
sequence length :
1684
purity :
Affinity purification
storage stability :
Store at -20°C. Avoid freeze / thaw cycles.
tested application :
ELISA (EIA), Immunohistochemistry (IHC)
app notes :
IHC 1:50-1:200
image1 heading :
Immunohistochemistry (IHC)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Synthetic peptide of human AKAP12
other info2 :
Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
products categories :
Epigenetics
products description :
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
ncbi gi num :
21493024
ncbi acc num :
NP_005091
ncbi gb acc num :
NM_144497.2
ncbi pathways :
G Protein Signaling Pathways (198849)
ncbi summary :
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
uniprot summary :
AKAP12: a scaffold protein that contains 3 conserved PKA binding motifs. Suppresses podosome formation, inhibits RhoA and Cdc42 activity, and inhibits v-Src-induced oncogenic growth in NIH3T3. May inhibit Src-induced oncogenesis by reestablishing actin-based non-invasive cytoskeletal architecture. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 6q24-q25. Cellular Component: focal adhesion; cytoskeleton; cytoplasm; plasma membrane; cell cortex. Molecular Function: protein binding; protein kinase A binding; adenylate cyclase binding. Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of cAMP biosynthetic process; protein targeting
size1 :
0.02 mL
price1 :
110 USD
size2 :
0.06 mL
price2 :
150
size3 :
0.12 mL
price3 :
225
size4 :
0.2 mL
price4 :
360
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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