antibody

MAP3K12 Polyclonal Antibody

MBS2522510

0.06 mL

195 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

ELISA, immunohistochemistry, enzyme immunoassay

Antibody

MAP3K12 Polyclonal Antibody

MAP3K12

DLK; MUK; ZPK; ZPKP1; MEKK12

MAP3K12 protein; Mitogen-activated protein kinase kinase kinase 12; mitogen-activated protein kinase kinase kinase 12; MAPK-upstream kinase; dual leucine zipper bearing kinase; dual leucine zipper kinase DLK; leucine zipper protein kinase; mixed lineage kinase; protein kinase MUK; mitogen-activated protein kinase kinase kinase 12; Dual leucine zipper bearing kinase; DLK; Leucine-zipper protein kinase; ZPK; MAPK-upstream kinase; MUK; Mixed lineage kinase

MAP3K12

MAP3K12; MAP3K12; DLK; MUK; ZPK; ZPKP1; MEKK12; ZPK; DLK; ZPK; MUK

M3K12_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

567

Antigen affinity purification

1.4mg/mL

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

ELISA (EIA), Immunohistochemistry (IHC)

IHC: 1:25-1:100

Background: This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.

29476775

AAH50050.1

Insulin Signaling Pathway (198845); MAPK (JNK) Signaling Pathway (1084764); MAPK (JNK) Signaling Pathway (1108227); MAPK (p38) Signaling Pathway (1084765); MAPK (p38) Signaling Pathway (1108228); MAPK Cascade Pathway (198834); MAPK Signaling Pathway (198779); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Regulation Of P38-alpha And P38-beta Pathway (137964)

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]

DLK: May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Protein type: Protein kinase, TKL; EC 2.7.11.25; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; LZK subfamily. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: growth cone; membrane; axon; cytoplasm; plasma membrane; cytosol. Molecular Function: protein serine/threonine kinase activity; protein binding; protein homodimerization activity; MAP kinase kinase kinase activity; protein kinase binding; ATP binding; protein kinase activity. Biological Process: peptidyl-serine phosphorylation; activation of MAPKK activity; histone phosphorylation; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation; JNK cascade; protein amino acid phosphorylation

0.06 mL

195 USD

0.12 mL

270

0.2 mL

435