catalog number :
MBS2522498
products full name :
GADD45G Polyclonal Antibody
products short name :
[GADD45G]
products name syn :
[CR6, DDIT2, GRP17, GADD45gamma]
other names :
[growth arrest and DNA damage-inducible protein GADD45 gamma; Growth arrest and DNA damage-inducible protein GADD45 gamma; growth arrest and DNA damage-inducible protein GADD45 gamma; DDIT-2; DNA damage-inducible transcript 2 protein; GADD45-gamma; cytokine-responsive protein CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible, gamma; Cytokine-responsive protein CR6; DNA damage-inducible transcript 2 protein; DDIT-2]
products gene name :
[GADD45G]
other gene names :
[GADD45G; GADD45G; CR6; DDIT2; GRP17; GADD45gamma; CR6; DDIT2; DDIT-2]
uniprot entry name :
GA45G_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Affinity purification
storage stability :
Store at -20 degree C. Avoid freeze / thaw cycles.
tested application :
ELISA (EIA), Immunohistochemistry (IHC)
app notes :
IHC: 1:100-1:200
image1 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Recombinant protein of human GADD45G
other info2 :
Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
products categories :
Cell biology; Epigenetics
products description :
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta.
ncbi acc num :
NP_006696.1
ncbi gb acc num :
NM_006705.3
uniprot acc num :
BC000465
ncbi pathways :
Cell Cycle Pathway (83054); Cell Cycle Pathway (463); DNA Damage Response Pathway (198788); FoxO Signaling Pathway (921162); IL12-mediated Signaling Events Pathway (137922); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); P38 MAPK Signaling Pathway (137943); P53 Signaling Pathway (83055); P53 Signaling Pathway (465)
ncbi summary :
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
uniprot summary :
GADD45G: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. Belongs to the GADD45 family. Protein type: Apoptosis; Nuclear receptor co-regulator; DNA repair, damage. Chromosomal Location of Human Ortholog: 9q22.1-q22.2. Cellular Component: cytoplasm; nucleus. Molecular Function: protein binding. Biological Process: activation of MAPKK activity; regulation of cell cycle; apoptosis; positive regulation of apoptosis; multicellular organismal development; activation of MAPKKK activity; response to stress; negative regulation of protein kinase activity; positive regulation of JNK cascade; cell differentiation