product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
PAPPA Polyclonal Antibody
catalog :
MBS2522483
quantity :
0.02 mL
price :
110 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS2522483 image 1
Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PAPPA Polyclonal Antibody at dilution of 1:50
image 2 :
MyBioSource MBS2522483 image 2
Immunohistochemistry of paraffin-embedded Human thyroid cancer using PAPPA Polyclonal Antibody at dilution of 1:50
image 3 :
MyBioSource MBS2522483 image 3
Immunohistochemistry of paraffin-embedded Human Placenta using PAPPA Polyclonal Antibody at dilution of 1:100
product information
catalog number :
MBS2522483
products type :
Antibody
products full name :
PAPPA Polyclonal Antibody
products short name :
[PAPPA]
products name syn :
[PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase]
other names :
[Pappalysin-1; Pappalysin-1; pappalysin-1; IGF-dependent IGFBP-4 protease; aspecific BCL2 ARE-binding protein 2; differentially placenta 1 expressed protein; insulin-like growth factor-dependent IGF binding protein-4 protease; insulin-like growth factor-dependent IGF-binding protein 4 protease; pregnacy-associated plasma protein A; pregnancy-associated plasma protein A, pappalysin 1; Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase; Pregnancy-associated plasma protein A; PAPP-A]
products gene name :
[PAPPA]
other gene names :
[PAPPA; PAPPA; PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase; IGF-dependent IGFBP-4 protease; IGFBP-4ase; PAPP-A]
uniprot entry name :
PAPP1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
1627
purity :
Affinity purification
storage stability :
Store at -20°C. Avoid freeze / thaw cycles.
tested application :
ELISA (EIA), Immunohistochemistry (IHC)
app notes :
IHC: 1:50-1:200
image1 heading :
Immunohistochemistry (IHC)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Synthetic peptide of human PAPPA
other info2 :
Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
products categories :
Epigenetics
products description :
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses.
ncbi gi num :
223590248
ncbi acc num :
NP_002572
ncbi pathways :
Metabolism Of Proteins Pathway (106230); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)
ncbi summary :
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]
uniprot summary :
PAPPA: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family. Protein type: Secreted, signal peptide; Secreted; EC 3.4.24.79; Protease. Chromosomal Location of Human Ortholog: 9q33.2. Cellular Component: membrane; extracellular region. Molecular Function: metallopeptidase activity; zinc ion binding; metalloendopeptidase activity. Biological Process: cellular protein metabolic process; female pregnancy; cell differentiation; proteolysis
size1 :
0.02 mL
price1 :
110 USD
size2 :
0.06 mL
price2 :
150
size3 :
0.12 mL
price3 :
225
size4 :
0.2 mL
price4 :
360
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!