ITPR2 Polyclonal Antibody | MyBioSource MBS2522256 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ITPR2 Polyclonal Antibody

catalog :

MBS2522256

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded Human colon cancer tissue using ITPR2 Polyclonal Antibody at dilution 1:40

product information

catalog number :

MBS2522256

products type :

Antibody

products full name :

ITPR2 Polyclonal Antibody

products short name :

[ITPR2]

products name syn :

[IP3R2]

other names :

[inositol 1,4,5-trisphosphate receptor type 2; Inositol 1,4,5-trisphosphate receptor type 2; inositol 1,4,5-trisphosphate receptor type 2; IP3 receptor; IP3R 2; cilia and flagella associated protein 48; inositol 1,4,5-triphosphate receptor, type 2; insP3R2; type 2 InsP3 receptor; type 2 inositol 1,4,5-trisphosphate receptor; inositol 1,4,5-trisphosphate receptor, type 2; IP3 receptor isoform 2; IP3R 2; InsP3R2; Type 2 inositol 1,4,5-trisphosphate receptor; Type 2 InsP3 receptor]

products gene name :

[ITPR2]

other gene names :

[ITPR2; ITPR2; IP3R2; CFAP48; IP3R 2; InsP3R2; Type 2 InsP3 receptor]

uniprot entry name :

ITPR2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

2701

purity :

Affinity purification

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

app notes :

IHC: 1:50-1:200

image1 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Synthetic peptide of human ITPR2

other info2 :

Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3

products description :

Inositol 1, 4, 5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4, 5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1, 4, 5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.

ncbi gi num :

95147335

ncbi acc num :

NP_002214

ncbi gb acc num :

NM_002223.2

ncbi mol weight :

20,608 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); B Cell Receptor Signaling Pathway (198909); Ca2+ Pathway (1127532); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459)

ncbi summary :

The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]

uniprot summary :

IP3R2: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA. Most normal tissues displayed weak to moderate cytoplasmic positivity. Strong staining was observed in the gastrointestinal tract, hepatocytes and exocrine pancreas. Short isoform Is found in skeletal muscle and heart. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA increases calcium release. Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor. Belongs to the InsP3 receptor family. 2 isoforms of the human protein are produced by alternative splicing. The short isoform is found in skeletal muscle and heart. Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass; Channel, calcium. Chromosomal Location of Human Ortholog: 12p11. Cellular Component: endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; membrane; integral to membrane; plasma membrane; cell cortex; receptor complex. Molecular Function: calcium ion transmembrane transporter activity; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity. Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; inositol phosphate-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; phospholipase C activation; transport; energy reserve metabolic process; response to hypoxia; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway; regulation of insulin secretion. Disease: Anhidrosis, Isolated, With Normal Sweat Glands

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage