product summary
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company name :
MyBioSource
product type :
antibody
product name :
MLKL Antibody
catalog :
MBS2522244
quantity :
0.06 mL
price :
150 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS2522244 image 1
Western blot analysis of extracts ofvarious cell lines with MLKLPolyclonal Antibody.
product information
catalog number :
MBS2522244
products type :
Antibody
products full name :
MLKL Antibody
products short name :
[MLKL]
products name syn :
[hMLKL]
other names :
[mixed lineage kinase domain-like protein isoform 2; Mixed lineage kinase domain-like protein; mixed lineage kinase domain-like protein; MLKL; mixed lineage kinase domain-like]
products gene name :
[MLKL]
other gene names :
[MLKL; MLKL; hMLKL; hMLKL]
uniprot entry name :
MLKL_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
sequence length :
263
purity :
Affinity purification
storage stability :
Store at -20°C. Avoid freeze / thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB 1:500 - 1:2000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant protein of human MLKL. Calculated MW: 53kDa/54kDa. Observed MW: 70 kDa
other info2 :
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-165025
products description :
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNFinduced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
ncbi gi num :
215820622
ncbi acc num :
NP_001135969.1
ncbi gb acc num :
NM_001142497.1
uniprot acc num :
Q9D2Y4
ncbi pathways :
DNA Damage Response (only ATM Dependent) Pathway (198827); TNF Signaling Pathway (812256); TNF Signaling Pathway (813210)
ncbi summary :
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
uniprot summary :
MLKL: Belongs to the protein kinase superfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; TKL-Unique family. Chromosomal Location of Human Ortholog: 16q23.1. Cellular Component: cytoplasm; plasma membrane. Molecular Function: protein binding; protein complex binding; protein kinase binding; ATP binding; protein kinase activity. Biological Process: protein amino acid phosphorylation
size1 :
0.06 mL
price1 :
150 USD
size2 :
0.12 mL
price2 :
225
size3 :
0.2 mL
price3 :
360
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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