catalog number :
MBS2521928
products full name :
DPEP1 Antibody
products short name :
[DPEP1]
products name syn :
[Dehydropeptidase I, Dipeptidase 1, dipeptidase 1,(renal), DPEP1, hRDP, MBD1, MDP, Microsomal,ipeptidase, RDP, Renal dipeptidase.]
other names :
[dipeptidase 1; Dipeptidase 1; dipeptidase 1; dehydropeptidase-I; hRDP; microsomal dipeptidase; renal dipeptidase; dipeptidase 1 (renal); Dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase; hRDP]
products gene name :
[DPEP1]
other gene names :
[DPEP1; DPEP1; MDP; RDP; MBD1; MDP; RDP; hRDP]
uniprot entry name :
DPEP1_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen affinity purification
form :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
storage stability :
Store at -20°C. Avoid freeze / thaw cycles
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:200-1:1000 . IHC: 1:100-1:400
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Fusion protein of DPEP1 . Calculated MW: 411aa,46 kDa . Observed MW: 46kd
other info2 :
Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-109262 / sc-109260
products description :
DPEP1(Dipeptidase 1) is also named as MDP, RDP and belongs to the peptidase M19 family. It is a glycoprotein that playis an important role in he regulation of leukotriene activity. DPEP1 converts lekotriene D4 to leukotriene E4.
ncbi gb acc num :
NM_001128141.2
ncbi pathways :
Aflatoxin Activation And Detoxification Pathway (1127511); Arachidonic Acid Metabolism Pathway (685553); Biological Oxidations Pathway (105698); Defective ACY1 Causes Encephalopathy Pathway (1127638); Disease Pathway (530764); Eicosanoid Synthesis Pathway (198888); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Synthesis Of Leukotrienes (LT) And Eoxins (EX) Pathway (730334)
ncbi summary :
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]
uniprot summary :
DPEP1: Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity. Belongs to the peptidase M19 family. Protein type: EC 3.4.13.19; Membrane protein, GPI anchor; Protease. Chromosomal Location of Human Ortholog: 16q24.3. Cellular Component: extracellular space; microvillus membrane; apical part of cell; apical plasma membrane; plasma membrane; nucleus; cell junction. Molecular Function: protein binding; metalloexopeptidase activity; zinc ion binding; dipeptidyl-peptidase activity; caspase inhibitor activity. Biological Process: glutathione metabolic process; xenobiotic metabolic process; arachidonic acid metabolic process; leukotriene metabolic process; homocysteine metabolic process; negative regulation of caspase activity; proteolysis; negative regulation of cell migration; antibiotic metabolic process; negative regulation of apoptosis