IGFBP3 Antibody | MyBioSource MBS2521889 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IGFBP3 Antibody

catalog :

MBS2521889

quantity :

0.06 mL

price :

195 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunofluorescent analysis of HeLa cells using IGFBP3 Polyclonal Antibody at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

image 2 :

Immunohistochemical of paraffinembedded human breast cancer using IGFBP3 Polyclonal Antibody at dilution of 1:50 (under 10x lens)

product information

catalog number :

MBS2521889

products type :

Antibody

products full name :

IGFBP3 Antibody

products short name :

[IGFBP3]

products name syn :

[BP53, IBP3, IBP 3, IGF binding protein 3, IGFBP 3, IGFBP3]

other names :

[insulin-like growth factor-binding protein 3 isoform a; Insulin-like growth factor-binding protein 3; insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3; acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; growth hormone-dependent binding protein; insulin-like growth factor binding protein 3]

products gene name :

[IGFBP3]

other gene names :

[IGFBP3; IGFBP3; IBP3; BP-53; IBP3; IBP-3; IGF-binding protein 3; IGFBP-3]

uniprot entry name :

IBP3_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

297

purity :

Antigen affinity purification

storage stability :

Store at -20°C. Avoid freeze / thaw cycles

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

WB: 1:200-1:1000 . IHC: 1:20-1:200 . IF : 1:10-1:100

image1 heading :

SDS-PAGE

image2 heading :

Immunofluorescence

image3 heading :

Immunohistochemical

other info2 :

Immunogen: Fusion protein of IGFBP3. Buffer: PBS with 0.1% sodium azide, 50% glycerol, pH 7.3

products description :

Background: Insulin-like growth factor binding protein-3 (IGFBP-3) contains a 27 amino acid putative signal sequence followed by a mature protein of 264 amino acids with 18 cysteine residues clustered near the N- and C-terminus. Accordingly, expression of the cloned IGFBP-3 cDNA in mammalian tissue culture cells results in secretion of the protein into the culture medium. IGFBP-3 shares high homology (33% amino acid identity) including conservation of all 18 cysteine residues with a smaller human IGF-binding protein (BP-28) identified in amniotic fluid.

ncbi gi num :

62243248

ncbi acc num :

NP_001013416.1

ncbi gb acc num :

NM_001013398.1

ncbi mol weight :

32 kDa

ncbi pathways :

Direct P53 Effectors Pathway (137939); Integrated Pancreatic Cancer Pathway (711360); Metabolism Of Proteins Pathway (106230); Myometrial Relaxation And Contraction Pathways (198759); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908); Senescence And Autophagy Pathway (198780); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987); P53 Signaling Pathway (83055); P53 Signaling Pathway (465)

ncbi summary :

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

uniprot summary :

IGFBP3: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Protein type: Secreted, signal peptide; Secreted; Cell development/differentiation. Chromosomal Location of Human Ortholog: 7p12.3. Cellular Component: insulin-like growth factor binding protein complex; extracellular space; extracellular region; nucleus. Molecular Function: insulin-like growth factor binding; protein binding; insulin-like growth factor I binding; metal ion binding; fibronectin binding; insulin-like growth factor II binding; protein tyrosine phosphatase activator activity. Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of catalytic activity; regulation of insulin-like growth factor receptor signaling pathway; apoptosis; negative regulation of smooth muscle cell proliferation; positive regulation of apoptosis; negative regulation of smooth muscle cell migration; protein amino acid phosphorylation; positive regulation of myoblast differentiation; negative regulation of signal transduction; osteoblast differentiation; negative regulation of cell proliferation; cellular protein metabolic process; positive regulation of MAPKKK cascade; negative regulation of protein amino acid phosphorylation; regulation of cell growth

size1 :

0.06 mL

price1 :

195 USD

size2 :

0.12 mL

price2 :

270

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage