product summary
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company name :
MyBioSource
product type :
antibody
product name :
MPO Polyclonal Antibody
catalog :
MBS2521613
quantity :
0.02 mL
price :
110 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS2521613 image 1
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MPO Polyclonal Antibody at dilution 1:50
image 2 :
MyBioSource MBS2521613 image 2
Immunohistochemistry of paraffin-embedded Human lung cancer tissue using MPO Polyclonal Antibody at dilution 1:50
product information
catalog number :
MBS2521613
products type :
Antibody
products full name :
MPO Polyclonal Antibody
products short name :
[MPO]
other names :
[myeloperoxidase; Myeloperoxidase; myeloperoxidase; myeloperoxidase]
products gene name :
[MPO]
other gene names :
[MPO; MPO; MPO]
uniprot entry name :
PERM_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
745
purity :
Affinity purification
concentration :
0.5mg/mL
storage stability :
Store at -20 degree C. Avoid freeze / thaw cycles.
tested application :
ELISA (EIA), Immunohistochemistry (IHC)
app notes :
IHC: 1:50-1:200
image1 heading :
Immunohistochemistry (IHC)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Recombinant protein of human MPO
other info2 :
Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
products categories :
Cancer
products description :
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils.
ncbi gi num :
4557759
ncbi acc num :
NP_000241.1
ncbi gb acc num :
NM_000250.1
uniprot acc num :
BC130476
ncbi mol weight :
87,248 Da
ncbi pathways :
C-MYB Transcription Factor Network Pathway (138073); Folate Metabolism Pathway (198833); IL23-mediated Signaling Events Pathway (138000); Phagosome Pathway (153910); Phagosome Pathway (153859); Selenium Pathway (198825); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987); Vitamin B12 Metabolism Pathway (920974); Amb2 Integrin Signaling Pathway (137945)
ncbi summary :
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
uniprot summary :
MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 1.11.2.2; Oxidoreductase. Chromosomal Location of Human Ortholog: 17q23.1. Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule. Molecular Function: heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding. Biological Process: response to food; respiratory burst during defense response; removal of superoxide radicals; hydrogen peroxide catabolic process; response to mechanical stimulus; response to lipopolysaccharide; response to yeast; defense response; response to oxidative stress; defense response to fungus; negative regulation of apoptosis; aging. Disease: Myeloperoxidase Deficiency; Alzheimer Disease
size1 :
0.02 mL
price1 :
110 USD
size2 :
0.06 mL
price2 :
150
size3 :
0.12 mL
price3 :
225
size4 :
0.2 mL
price4 :
360
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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