SLC34A2 Polyclonal Antibody | MyBioSource MBS2521543 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SLC34A2 Polyclonal Antibody

catalog :

MBS2521543

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using SLC34A2 Polyclonal Antibody at dilution of 1:50

image 2 :

Immunohistochemistry of paraffin-embedded Human ovarian cancer using SLC34A2 Polyclonal Antibody at dilution of 1:50

image 3 :

Immunohistochemistry of paraffin-embedded Human Lung tissue using SLC34A2 Polyclonal Antibody at dilution of 1:60

product information

catalog number :

MBS2521543

products type :

Antibody

products full name :

SLC34A2 Polyclonal Antibody

products short name :

[SLC34A2]

products name syn :

[NPTIIb,NAPI-3B,NAPI-IIb]

other names :

[sodium-dependent phosphate transport protein 2B isoform b; Sodium-dependent phosphate transport protein 2B; sodium-dependent phosphate transport protein 2B; sodium/phosphate cotransporter 2B; solute carrier family 34 (sodium phosphate), member 2; type II sodium-dependent phosphate transporter 3b; solute carrier family 34 (type II sodium/phosphate cotransporter), member 2; Na(+)-dependent phosphate cotransporter 2B; NaPi3b; Sodium/phosphate cotransporter 2B; Na(+)/Pi cotransporter 2B; NaPi-2b; Solute carrier family 34 member 2]

products gene name :

[SLC34A2]

other gene names :

[SLC34A2; SLC34A2; NPTIIb; NAPI-3B; NAPI-IIb; Sodium-phosphate transport protein 2B; Na(+)/Pi cotransporter 2B; NaPi-2b]

uniprot entry name :

NPT2B_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

purity :

Affinity purification

form :

PBS with 0.05% sodium azide, 50% glycerol, PH7.3

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

app notes :

IHC: 1:50-1:200

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Synthetic peptide of human SLC34A2

products categories :

Cancer

products description :

The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene.

ncbi gi num :

295789160

ncbi acc num :

NP_001171469

ncbi gb acc num :

NM_001177999.1

uniprot acc num :

O95436

ncbi pathways :

Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); SLC-mediated Transmembrane Transport Pathway (119558); Sodium-coupled Phosphate Cotransporters Pathway (119565); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway (119559); Type II Na+/Pi Cotransporters Pathway (119566)

ncbi summary :

uniprot summary :

SLC34A2: May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs alveoli. Defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis (PALM). Pulmonary alveolar microlithiasis is a rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early onset or rapid progression are rare. A sandstorm-appearing chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance. A chromosomal aberration involving SLC34A2 is found in a non-small cell lung cancer cell line. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity. Belongs to the SLC34A transporter family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family. Chromosomal Location of Human Ortholog: 4p15.2. Cellular Component: microvillus membrane; integral to plasma membrane; brush border membrane; apical plasma membrane; integral to membrane; plasma membrane; vesicle. Molecular Function: protein domain specific binding; sodium ion binding; phosphate binding; sodium:phosphate symporter activity; sodium-dependent phosphate transmembrane transporter activity. Biological Process: cellular phosphate ion homeostasis; phosphate transport; response to estrogen stimulus; in utero embryonic development; ion transport; transmembrane transport; response to fructose stimulus; response to estradiol stimulus; aging. Disease: Pulmonary Alveolar Microlithiasis; Testicular Microlithiasis

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage