S100A12 Polyclonal Antibody | MyBioSource MBS2521529 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

S100A12 Polyclonal Antibody

catalog :

MBS2521529

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded Human breast cancer tissue using S100A12 Polyclonal Antibody at dilution 1:45

image 2 :

Immunohistochemistry of paraffin-embedded Spleen tissue using S100A12 Polyclonal Antibody at dilution of 1:60(Detected by lifespan)

product information

catalog number :

MBS2521529

products type :

Antibody

products full name :

S100A12 Polyclonal Antibody

products short name :

[S100A12]

products name syn :

[p6; CAGC; CGRP; MRP6; CAAF1; MRP-6; ENRAGE]

other names :

[S100 calcium binding protein A12; Protein S100-A12; protein S100-A12; EN-RAGE; S100 calcium-binding protein A12 (calgranulin C); calcitermin; calcium-binding protein in amniotic fluid 1; calgranulin-C; extracellular newly identified RAGE-binding protein; migration inhibitory factor-related protein 6; neutrophil S100 protein; S100 calcium binding protein A12; CGRP; Calcium-binding protein in amniotic fluid 1; CAAF1; Calgranulin-C; CAGC; Extracellular newly identified RAGE-binding protein; EN-RAGE; Migration inhibitory factor-related protein 6; MRP-6; p6; Neutrophil S100 protein; S100 calcium-binding protein A12Calcitermin]

products gene name :

[S100A12]

other gene names :

[S100A12; S100A12; p6; CAGC; CGRP; MRP6; CAAF1; MRP-6; ENRAGE; CAAF1; CAGC; EN-RAGE; MRP-6; p6]

uniprot entry name :

S10AC_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

purity :

Affinity purification

form :

PBS with 0.05% sodium azide, 50% glycerol, PH7.3

storage stability :

Store at -20°C. Avoid freeze/thaw cycles

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

app notes :

IHC: 1:25-1:100

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

products description :

Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.

ncbi gi num :

47124555

ncbi acc num :

AAH70294.1

uniprot acc num :

BC070294

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Advanced Glycosylation Endproduct Receptor Signaling Pathway (187092); Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway (833822); Immune System Pathway (106386); Innate Immune System Pathway (106387); MyD88 Cascade Initiated On Plasma Membrane Pathway (205107); MyD88 Dependent Cascade Initiated On Endosome Pathway (187081); MyD88-independent Cascade Pathway (106401); MyD88:Mal Cascade Initiated On Plasma Membrane Pathway (106390)

ncbi summary :

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014]

uniprot summary :

S100A12: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. Belongs to the S-101 family. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: cytoskeleton; cytoplasm; plasma membrane; extracellular region; cytosol; nucleus. Molecular Function: RAGE receptor binding; protein binding; copper ion binding; zinc ion binding; calcium ion binding. Biological Process: neutrophil chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB cascade; killing of cells of another organism; mast cell activation; activation of NF-kappaB transcription factor; positive regulation of MAP kinase activity; monocyte chemotaxis; xenobiotic metabolic process; defense response to bacterium; innate immune response; inflammatory response; defense response to fungus; cytokine secretion; positive regulation of inflammatory response

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage