ITPR3 Polyclonal Antibody | MyBioSource MBS2521465 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ITPR3 Polyclonal Antibody

catalog :

MBS2521465

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded Human brain tissue using ITPR3 Polyclonal Antibody at dilution 1:30

image 2 :

Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ITPR3 Polyclonal Antibody at dilution 1:30

product information

catalog number :

MBS2521465

products type :

Antibody

products full name :

ITPR3 Polyclonal Antibody

products short name :

[ITPR3]

products name syn :

[IP3R; IP3R3]

other names :

[ITPR3 protein, partial; Inositol 1,4,5-trisphosphate receptor type 3; inositol 1,4,5-trisphosphate receptor type 3; IP3 receptor; inositol 1,4,5-triphosphate receptor, type 3; insP3R3; type 3 InsP3 receptor; inositol 1,4,5-trisphosphate receptor, type 3; IP3 receptor isoform 3; IP3R 3; InsP3R3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor]

products gene name :

[ITPR3]

other gene names :

[ITPR3; ITPR3; IP3R; IP3R3; IP3R 3; InsP3R3; Type 3 InsP3 receptor]

uniprot entry name :

ITPR3_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

1049

purity :

Affinity purification

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

app notes :

IHC: 1:50-1:200

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Synthetic peptide of human ITPR3

other info2 :

Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3

products description :

This gene encodes a receptor for inositol 1, 4, 5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1, 4, 5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.

ncbi gi num :

148921515

ncbi acc num :

AAI46647.1

ncbi mol weight :

304,106 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); Ca2+ Pathway (1127532); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cholinergic Synapse Pathway (217716)

ncbi summary :

This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

uniprot summary :

IP3R3: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Expressed in intestinal crypt and villus epithelial cells. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues. Belongs to the InsP3 receptor family. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated; Channel, calcium. Chromosomal Location of Human Ortholog: 6p21. Cellular Component: nuclear outer membrane; endoplasmic reticulum membrane; endoplasmic reticulum; integral to plasma membrane; nucleoplasm; cell soma; membrane; apical part of cell; cytoplasm; nucleolus; plasma membrane; brush border; receptor complex; myelin sheath. Molecular Function: protein binding; inositol 1,3,4,5 tetrakisphosphate binding; inositol hexakisphosphate binding; intracellular ligand-gated calcium channel activity; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity. Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; inositol phosphate-mediated signaling; sensory perception of umami taste; sensory perception of sweet taste; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; protein heterooligomerization; signal transduction; memory; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; phospholipase C activation; energy reserve metabolic process; innate immune response; sensory perception of bitter taste; vascular endothelial growth factor receptor signaling pathway; response to calcium ion; blood coagulation; regulation of insulin secretion; protein homooligomerization. Disease: Diabetes Mellitus, Insulin-dependent

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage