product summary
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company name :
MyBioSource
product type :
antibody
product name :
CNOT1 Antibody
catalog :
MBS2521164
quantity :
0.06 mL
price :
195 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
image
image 1 :
Western Blot analysis of human brain tissue,using CNOT1 Polyclonal Antibody at dilution of 1:800.
image 2 :
Immunohistochemistry of paraffin-embedded human heart tissue slide, using CNOT1 Polyclonal Antibody at dilution of 1:200.
product information
catalog number :
MBS2521164
products type :
Antibody
products full name :
CNOT1 Antibody
products short name :
[CNOT1]
products name syn :
[AD-005; CDC39; DKFZp686E0722; DKFZp686O168; FLJ36492; FLJ90644; KIAA1007; NOT1; NOT1H]
other names :
[CCR4-NOT transcription complex subunit 1 isoform c; CCR4-NOT transcription complex subunit 1; CCR4-NOT transcription complex subunit 1; CCR4-associated factor 1; NOT1 (negative regulator of transcription 1, yeast) homolog; adrenal gland protein AD-005; negative regulator of transcription subunit 1 homolog; CCR4-NOT transcription complex, subunit 1; CCR4-associated factor 1; Negative regulator of transcription subunit 1 homolog; NOT1H; hNOT1]
products gene name :
[CNOT1]
other gene names :
[CNOT1; CNOT1; NOT1; CDC39; NOT1H; AD-005; CDC39; KIAA1007; NOT1; NOT1H; hNOT1]
uniprot entry name :
CNOT1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
2371
purity :
Antigen affinity purification
form :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
storage stability :
Store at -20°C. Avoid freeze / thaw cycles
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:200-1:2000. IHC: 1:20-1:200
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Fusion protein of CNOT1. Calculated MW: 267. Observed MW: 240-250kd; 174kd
other info2 :
Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-242483
products description :
CNOT1 is a component of CCR4-NOT protein complex, which is a regulator of RNA polymerase II transcription, acts as a transcription repressor. CCR4-NOT complex could participate in transcription as well as mRNA degradation. It's highly expressed in brain, heart, thymus, but weak in skeletal muscle and colon. CNOT1 undergoes alternative splicing to produce four isoforms.This is a rabbit polyclonal antibody raised against part chain of C-terminal CNOT1 of human origin. CNOT1 exsits as many isoforms and molecular weight of isoforms are 267, 241 and 173 kDa.
ncbi gi num :
388454220
ncbi acc num :
NP_001252541.1
ncbi gb acc num :
NM_001265612.1
ncbi pathways :
Deadenylation Of MRNA Pathway (160994); Deadenylation-dependent MRNA Decay Pathway (160993); Gene Expression Pathway (105937); RNA Degradation Pathway (117291); RNA Degradation Pathway (116127)
uniprot summary :
NOT1: represses ligand-dependent transcriptional activation by oestrogen receptor (ER) alpha and several RXR heterodimers. Interacts with the ligand-binding domain of estrogen receptor-alpha in a hormone-dependent fashion. Protein type: RNA-binding; Transcription, coactivator/corepressor; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 16q21. Cellular Component: nucleoplasm; peroxisomal membrane; extracellular space; membrane; cytosol; CCR4-NOT complex. Molecular Function: protein domain specific binding; protein binding; poly(A)-specific ribonuclease activity; retinoic acid receptor binding; estrogen receptor binding; protein complex scaffold. Biological Process: negative regulation of retinoic acid receptor signaling pathway; poly(A) tail shortening; transcription, DNA-dependent; negative regulation of translation; multicellular organismal development; gene expression; negative regulation of transcription from RNA polymerase II promoter; miRNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay; negative regulation of estrogen receptor signaling pathway
size1 :
0.06 mL
price1 :
195 USD
size2 :
0.12 mL
price2 :
270
size3 :
0.2 mL
price3 :
435
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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