antibody

MTNR1A Polyclonal Antibody

MBS2521011

0.02 mL

110 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

MTNR1A Polyclonal Antibody

[MTNR1A]

[MT1, MEL-1A-R]

[melatonin receptor type 1A; Melatonin receptor type 1A; melatonin receptor type 1A; mel1a receptor; melatonin receptor 1A]

[MTNR1A]

[MTNR1A; MTNR1A; MT1; MEL-1A-R; Mel-1A-R; Mel1a receptor]

MTR1A_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

350

Affinity purification

1mg/mL

Store at -20°C. Avoid freeze / thaw cycles.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

WB 1:1000-1:3000, IHC 1:100-1:300

Western Blot (WB)

Immunohistochemistry (IHC)

Immunogen: Synthetic peptide of human MTNR1A

Buffer: PBS with 0.05% sodium azide, 50% glycerol, PH7.3

This gene encodes one of two high affinity forms of a receptor formelatonin, the primary hormone secreted by the pineal gland. Thisreceptor is a G-protein coupled, 7-transmembrane receptor that isresponsible for melatonin effects on mammalian circadian rhythm andreproductive alterations affected by day length. The receptor is an integralmembrane protein that is readily detectable and localized to two specificregions of the brain. The hypothalamic suprachiasmatic nucleus appearsto be involved in circadian rhythm while the hypophysial pars tuberalismay be responsible for the reproductive effects of melatonin.

5174593

NP_005949

NM_005958.3

P48039

39kDa

Circadian Entrainment Pathway (698773); Circadian Entrainment Pathway (699872); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637)

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

MTNR1A: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 4q35.1. Cellular Component: integral to plasma membrane; plasma membrane; receptor complex. Molecular Function: protein binding; hormone binding; melatonin receptor activity. Biological Process: circadian rhythm; G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of cGMP biosynthetic process; mating behavior

0.02 mL

110 USD

0.06 mL

150

0.12 mL

225

0.2 mL

360