DKK1 Antibody | MyBioSource MBS2521001 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

DKK1 Antibody

catalog :

MBS2521001

quantity :

0.06 mL

price :

195 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2521001

products type :

Antibody

products full name :

DKK1 Antibody

products short name :

DKK1

products name syn :

DKK-1; SK

other names :

dickkopf-related protein 1; Dickkopf-related protein 1; dickkopf-related protein 1; dickkopf 1 homolog; dickkopf related protein-1; dickkopf-1 like; dickkopf-like protein 1; hDkk-1; dickkopf WNT signaling pathway inhibitor 1; SK

products gene name :

DKK1

other gene names :

DKK1; DKK1; SK; DKK-1; Dickkopf-1; Dkk-1; hDkk-1

uniprot entry name :

DKK1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

266

purity :

Antigen affinity purification

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles

tested application :

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

app notes :

WB: 1:200-1:2000. IF: 1:20-1:50

products description :

Background/Introduction: DKK1, also named a SK and Dickkopf-1, belongs to the dickkopf family. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. SDS-PAGE and Western blot analysis demonstrated that DKK1 is expressed as a 35-kD doublet protein, which is larger than the deduced molecular mass of 26 kD. Sometime DKK1 is expressed as a 42- to 50-kD secreted protein, with little change observed after glycanase treatment.

ncbi gi num :

7110719

ncbi acc num :

NP_036374.1

ncbi gb acc num :

NM_012242.2

ncbi pathways :

Cardiac Progenitor Differentiation Pathway (712094); Direct P53 Effectors Pathway (137939); Disease Pathway (530764); Presenilin Action In Notch And Wnt Signaling Pathway (137914); RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway (1127632); Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway (169352); Signal Transduction Pathway (477114); Signaling By WNT In Cancer Pathway (1127614); Signaling By Wnt Pathway (106510); TCF Dependent Signaling In Response To WNT Pathway (1127516)

ncbi summary :

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]

uniprot summary :

DKK1: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling. Placenta. Belongs to the dickkopf family. Protein type: Secreted, signal peptide; Inhibitor; Secreted. Chromosomal Location of Human Ortholog: 10q11.2. Cellular Component: extracellular space; early endosome membrane; plasma membrane; extracellular region. Molecular Function: signal transducer activity; receptor antagonist activity; protein binding; growth factor activity; low-density lipoprotein receptor binding. Biological Process: negative regulation of skeletal muscle development; cellular morphogenesis during differentiation; response to retinoic acid; negative regulation of Wnt receptor signaling pathway; regulation of receptor internalization; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of BMP signaling pathway; hair follicle development; negative regulation of mesodermal cell fate specification; mesoderm formation; endoderm formation; forebrain development; regulation of endodermal cell fate specification; negative regulation of protein complex assembly; embryonic limb morphogenesis

size1 :

0.06 mL

price1 :

195 USD

size2 :

0.12 mL

price2 :

270

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage