catalog number :
MBS2520763
products full name :
CHCHD2 Antibody
products short name :
CHCHD2
products name syn :
C7orf17
other names :
coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial; Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial; coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial; 16.7kD protein; HCV NS2 trans-regulated protein; NS2TP; aging-associated gene 10 protein; coiled-coil-helix-coiled-coil-helix domain containing 2; Aging-associated gene 10 protein; HCV NS2 trans-regulated protein; NS2TP
products gene name :
CHCHD2
other gene names :
CHCHD2; CHCHD2; C7orf17; C7orf17; NS2TP
uniprot entry name :
CHCH2_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen affinity purification
storage stability :
Store at -20 degree C. Avoid freeze / thaw cycles
tested application :
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
app notes :
WB: 1:200-1:2000. IF: 1:50-1:500
other info1 :
Immunogen: Fusion protein of CHCHD2. Calculated Molecular Weight: 151aa; 16kd. Observed Molecular Weight: 16-18kd
other info2 :
Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
products description :
CHCHD2 is a widely expressed 16.7-kDa mitochondrion-localized protein. CHCHD2 contains a C-terminal CHCH (coiled-coil helix coiled-coil helix) domain. The function of the CHCH domain is not well understood, and the few characterized proteins that harbor this domain have diverse functions. Mutations in CHCHD2 gene have been reported in autosomal dominant Parkinson's disease (ADPD).
ncbi acc num :
NP_057223.1
ncbi gb acc num :
NM_016139.2
uniprot acc num :
BC003079
ncbi mol weight :
15,513 Da
uniprot summary :
CHCHD2: Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). {ECO:0000269 PubMed:23303788}. Up-regulated by hypoxia (4% oxygen) (at protein level). {ECO:0000269 PubMed:23303788}. Interacts with RBPJ. {ECO:0000269 PubMed:23303788}. Protein type: Unknown function. Chromosomal Location of Human Ortholog: 7p11.2. Cellular Component: mitochondrion