PVR Antibody | MyBioSource MBS2520722 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PVR Antibody

catalog :

MBS2520722

quantity :

0.06 mL

price :

150 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of various cell lines, using PVR antibody.

product information

catalog number :

MBS2520722

products type :

Antibody

products full name :

PVR Antibody

products short name :

[PVR]

products name syn :

[PVS; HVED; CD155; NECL5; TAGE4; Necl-5]

other names :

[poliovirus receptor isoform delta; Poliovirus receptor; poliovirus receptor; nectin-like protein 5; poliovirus receptor; Nectin-like protein 5; NECL-5; CD_antigen: CD155]

products gene name :

[PVR]

other gene names :

[PVR; PVR; PVS; HVED; CD155; NECL5; TAGE4; Necl-5; PVS; NECL-5]

uniprot entry name :

PVR_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

392

purity :

Affinity purification

concentration :

1mg/mL

storage stability :

Store at -20 degree C. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500-1:2000. IHC: 1:50-1:200

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: Recombinant protein of human PVR. Calculated MW: 45kDa. Observed MW: Refer to Figures

other info2 :

Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3

products description :

The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.

ncbi gi num :

609878416

ncbi acc num :

NP_001129242.2

ncbi gb acc num :

NM_001135770.3

ncbi mol weight :

42,864 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Adherens Junctions Interactions Pathway (119533); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132); Cell-cell Junction Organization Pathway (119532); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413); Nectin Adhesion Pathway (138054)

ncbi summary :

uniprot summary :

PVR: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. Belongs to the nectin family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Immunoglobulin superfamily; Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: extracellular space; focal adhesion; cell surface; cytoplasm; integral to membrane; plasma membrane. Molecular Function: viral receptor activity; protein binding; receptor activity; cell adhesion molecule binding. Biological Process: intercellular junction assembly and maintenance; cell migration; cell-cell adhesion; entry of virus into host cell; regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; response to virus; susceptibility to natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity

size1 :

0.06 mL

price1 :

150 USD

size2 :

0.12 mL

price2 :

225

size3 :

0.2 mL

price3 :

360

more info or order :

MyBioSource product webpage