FZD5 Antibody | MyBioSource MBS2520484 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FZD5 Antibody

catalog :

MBS2520484

quantity :

0.06 mL

price :

195 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

COLO 320 cells were subjected to SDS-PAGE followed by western blot with FZD5 Antibody at dilution of 1:600

product information

catalog number :

MBS2520484

products type :

Antibody

products full name :

FZD5 Antibody

products short name :

[FZD5]

products name syn :

[C2orf31; DKFZp434E2135; HFZ5; MGC129692]

other names :

[frizzled-5; Frizzled-5; frizzled-5; Wnt receptor; frizzled 5, seven transmembrane spanning receptor; frizzled family receptor 5; fz-5; fzE5; seven-transmembrane receptor frizzled-5; frizzled class receptor 5; FzE5]

products gene name :

[FZD5]

other gene names :

[FZD5; FZD5; HFZ5; C2orf31; C2orf31; Fz-5; hFz5]

uniprot entry name :

FZD5_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

585

purity :

Antigen affinity purification

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

WB: 1:200-1:2000

image1 heading :

Testing Data

other info1 :

Immunogen: Fusion protein of FZD5. Calculated Molecular Weight: 585aa; 65kd. Observed MW: 65kD

other info2 :

Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23222 / sc-23223

products description :

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.

ncbi gi num :

27894385

ncbi acc num :

NP_003459.2

ncbi gb acc num :

NM_003468.3

ncbi pathways :

Asymmetric Localization Of PCP Proteins Pathway (1127529); Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Ca2+ Pathway (1127532); Canonical Wnt Signaling Pathway (138032); Class B/2 (Secretin Family Receptors) Pathway (106378); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); GPCR Ligand Binding Pathway (161020); HTLV-I Infection Pathway (373901)

ncbi summary :

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]

uniprot summary :

FZD5: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. Interacts with GOPC. Belongs to the G-protein coupled receptor Fz/Smo family. Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, Fz/Smo family; Receptor, GPCR. Chromosomal Location of Human Ortholog: 2q33.3. Cellular Component: Golgi membrane; cell surface; tight junction; perinuclear region of cytoplasm; early endosome membrane; integral to membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; protein binding; Wnt receptor activity; ubiquitin protein ligase binding; protein kinase binding. Biological Process: positive regulation of JNK activity; post-embryonic camera-type eye development; cell maturation; embryonic axis specification; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; embryonic camera-type eye development; neuron differentiation; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; positive regulation of interferon-gamma production; determination of anterior/posterior axis, embryo; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; Spemann organizer formation

size1 :

0.06 mL

price1 :

195 USD

size2 :

0.12 mL

price2 :

270

size3 :

0.2 mL

price3 :

435

more info or order :

MyBioSource product webpage