product summary
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company name :
MyBioSource
product type :
antibody
product name :
CCBL1 Antibody
catalog :
MBS2520422
quantity :
0.06 mL
price :
195 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, enzyme immunoassay
more info or order :
image
image 1 :
mouse kidney tissue were subjected to SDS-PAGE followed by western blot CCBL1 Antibody: at dilution of 1 :600
image 2 :
Immunofluorescent analysis of (-20 degree C Ethanol) fixed HeLa cells using CCBL 1 Antibody at dilution of 1:50 and Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L)
product information
catalog number :
MBS2520422
products type :
Antibody
products full name :
CCBL1 Antibody
products short name :
[CCBL1]
products name syn :
[FLJ95217; GTK; KAT1; KATI; MGC29624]
other names :
[CCBL1 protein; Kynurenine--oxoglutarate transaminase 1; kynurenine--oxoglutarate transaminase 1; beta-lysase, kidney; cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); cysteine-S-conjugate beta-lyase; glutamine--phenylpyruvate transaminase; glutamine-phenylpyruvate aminotransferase; kynurenine aminotransferase I; kynurenine--oxoglutarate transaminase I; cysteine conjugate-beta lyase, cytoplasmic; Cysteine-S-conjugate beta-lyase (EC:4.4.1.13); Glutamine transaminase K; GTK; Glutamine--phenylpyruvate transaminase (EC:2.6.1.64); Kynurenine aminotransferase I; KATI; Kynurenine--oxoglutarate transaminase I]
products gene name :
[CCBL1]
other gene names :
[CCBL1; CCBL1; GTK; KAT1; KATI; GTK; KATI]
uniprot entry name :
KAT1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
250
purity :
Antigen affinity purification
storage stability :
Store at -20 degree C. Avoid freeze / thaw cycles
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
WB: 1:200-1:2000. IF: 1:50-1:500
image1 heading :
Testing Data
image2 heading :
Immunofluorescence
other info1 :
Immunogen: Fusion protein of CCBL1. Calculated Molecular Weight: 48kd. Observed Molecular Weight: 48kd
other info2 :
Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
products description :
CCBL 1 encodes kynurenine aminotransferase 1 (KAT 1), a key enzyme involved in kynurenine pathway. CCBL 1 catalyzes the production of kynurenic acid, a powerful endogenous excitatory amino acid receptor antagonist that is widely regarded as the potent neuroprotective agent.
ncbi gi num :
33879193
ncbi acc num :
BC013069
uniprot acc num :
Q16773
ncbi pathways :
Abnormal Metabolism In Phenylketonuria Pathway (645287); Amino Acid Synthesis And Interconversion (transamination) Pathway (106173); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Disease Pathway (530764); L-kynurenine Degradation Pathway (907939); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Phenylalanine And Tyrosine Catabolism Pathway (106189)
ncbi summary :
This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
CCBL1: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 2.6.1.64; EC 2.6.1.7; Lyase; Transferase; EC 4.4.1.13. Chromosomal Location of Human Ortholog: 9q34.11. Cellular Component: nucleoplasm; cytoplasm; cytosol. Molecular Function: cysteine-S-conjugate beta-lyase activity; protein homodimerization activity; kynurenine-oxoglutarate transaminase activity; glutamine-pyruvate transaminase activity; glutamine-phenylpyruvate transaminase activity; transaminase activity; phenylalanine(histidine) transaminase activity; pyridoxal phosphate binding. Biological Process: L-phenylalanine catabolic process; amino acid biosynthetic process; tryptophan catabolic process; amino acid derivative metabolic process
size1 :
0.06 mL
price1 :
195 USD
size2 :
0.12 mL
price2 :
270
size3 :
0.2 mL
price3 :
435
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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