GREM1 Polyclonal Antibody | MyBioSource MBS2520379 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GREM1 Polyclonal Antibody

catalog :

MBS2520379

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of Mouse testis tissue using GREM1 Polyclonal Antibody at dilution of 1:700

product information

catalog number :

MBS2520379

products type :

Antibody

products full name :

GREM1 Polyclonal Antibody

products short name :

[GREM1]

products name syn :

[DRM; PIG2; DAND2; IHG-2; GREMLIN; CKTSF1B1]

other names :

[gremlin-1 isoform 2; Gremlin-1; gremlin-1; DAN domain family member 2; cell proliferation-inducing gene 2 protein; colorectal adenoma and carcinoma 1; cysteine knot superfamily 1, BMP antagonist 1; down-regulated in Mos-transformed cells protein; gremlin 1, cysteine knot superfamily, homolog; gremlin 1-like protein; increased in high glucose-2; gremlin 1, DAN family BMP antagonist; Cell proliferation-inducing gene 2 protein; Cysteine knot superfamily 1, BMP antagonist 1; DAN domain family member 2; Down-regulated in Mos-transformed cells protein; Increased in high glucose protein 2; IHG-2]

products gene name :

[GREM1]

other gene names :

[GREM1; GREM1; DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1; CKTSF1B1; DAND2; DRM; IHG-2]

uniprot entry name :

GREM1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

143

purity :

Affinity purification

storage stability :

Store at -20°C Avoid freeze / thaw cycles.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

WB: 1:500-1:2000

image1 heading :

Western Blot (WB)

other info1 :

Immunogen: Recombinant protein of human GREM1. Calculated MW: 21kDa

other info2 :

Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3

products categories :

Stem cells

products description :

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

ncbi gi num :

300797328

ncbi acc num :

BC069525

ncbi gb acc num :

NM_001191323.1

uniprot acc num :

O60565

ncbi pathways :

BMP Receptor Signaling Pathway (137948)

ncbi summary :

uniprot summary :

GREM1: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis. Interacts with SLIT1 and SLIT2 in a glycosylation- dependent manner. By high glucose through TGFB1-mediated pathways in mesangial cell. Down-regulated in tumor cell lines. Highly expressed in small intestine, fetal brain and colon. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts. Belongs to the DAN family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 15q13.3. Cellular Component: extracellular space; cell surface. Molecular Function: morphogen activity; transmembrane receptor protein tyrosine kinase activator activity; protein binding; vascular endothelial growth factor receptor 2 binding; cytokine activity; receptor agonist activity. Biological Process: limb development; transmembrane receptor protein tyrosine kinase activation (dimerization); collagen fibril organization; apoptosis; positive regulation of receptor internalization; negative regulation of chondrocyte differentiation; cell morphogenesis; positive regulation of NF-kappaB import into nucleus; signal transduction; negative regulation of BMP signaling pathway; activation of NF-kappaB transcription factor; negative regulation of bone mineralization; cell-cell signaling; positive regulation of cell proliferation; proximal/distal pattern formation; embryonic limb morphogenesis; determination of dorsal identity; positive regulation of telomerase activity; regulation of stress-activated MAPK cascade; positive regulation of angiogenesis; cell migration during sprouting angiogenesis; ureteric bud branching; negative regulation of bone remodeling; regulation of focal adhesion formation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of osteoblast proliferation; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage