PTCH1 Polyclonal Antibody | MyBioSource MBS2520173 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PTCH1 Polyclonal Antibody

catalog :

MBS2520173

quantity :

0.02 mL

price :

110 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of Hela cell and Mouse lung tissue using PTCH1 Polyclonal Antibody at dilution of 1:900

image 2 :

Immunohistochemistry of paraffin-embedded Human ovarian cancer using PTCH1 Polyclonal Antibody at dilution of 1:50

image 3 :

Immunohistochemistry of paraffin-embedded Human thyroid cancer using PTCH1 Polyclonal Antibody at dilution of 1:50

product information

catalog number :

MBS2520173

products type :

Antibody

products full name :

PTCH1 Polyclonal Antibody

products short name :

[PTCH1]

products name syn :

[PTC, BCNS, HPE7, PTC1, PTCH, NBCCS, PTCH11]

other names :

[protein patched homolog 1 isoform S; Protein patched homolog 1; protein patched homolog 1; PTCH protein +12b; PTCH protein +4'; PTCH protein -10; PTCH protein -3,4,5; patched 1]

products gene name :

[PTCH1]

other gene names :

[PTCH1; PTCH1; PTC; BCNS; HPE7; PTC1; PTCH; NBCCS; PTCH11; PTCH; PTC; PTC1]

uniprot entry name :

PTC1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

1296

purity :

Affinity purification

form :

PBS with 0.05% sodium azide, 50% glycerol, pH7.3

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500-1:2000. IHC: 1:50-1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Recombinant protein of human PTCH1

products categories :

Stem cells; Cancer; Cell biology

products description :

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

ncbi gi num :

134254468

ncbi acc num :

BC043542

ncbi gb acc num :

NM_001083605.1

uniprot acc num :

Q13635

ncbi mol weight :

161kDa

ncbi pathways :

Activation Of SMO Pathway (1127544); Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Class B/2 (Secretin Family Receptors) Pathway (106378); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); Endochondral Ossification Pathway (198812); GPCR Ligand Binding Pathway (161020); Glypican 3 Network Pathway (138084); Hedgehog 'off' State Pathway (1127538)

ncbi summary :

uniprot summary :

PTCH1: a multi-pass membrane protein member of the ?patched? family that acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog protein?s signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. Interacts with SNX17. Expressed in tumor cells but not in normal skin. In the embryo, found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud. Defects in PTCH1 are the cause of basal cell nevus syndrome (BCNS), also known as Gorlin syndrome. BCNS is an autosomal dominant disease characterized by nevoid basal cell carcinomas and developmental abnormalities such as rib and craniofacial alterations, polydactyly, syndactyly, and spina bifida. In addition, the patients suffer from a multitude of tumors like basal cell carcinomas, fibromas of the ovaries and heart, cysts of the skin, jaws and mesentery, as well as medulloblastomas and meningiomas. PTCH1 defects is also the cause of holoprosencephaly, the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Protein type: Tumor suppressor; Cell cycle regulation; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 9q22.3. Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; perinuclear region of cytoplasm; postsynaptic density; integral to membrane; plasma membrane; midbody; caveola. Molecular Function: heparin binding; cyclin binding; protein binding; hedgehog receptor activity; cholesterol binding; protein complex binding; patched binding; smoothened binding. Biological Process: heart morphogenesis; hindlimb morphogenesis; epidermis development; regulation of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; response to chlorate; response to estradiol stimulus; regulation of protein localization; negative regulation of osteoblast differentiation; negative regulation of epithelial cell proliferation; embryonic limb morphogenesis; response to drug; smoothened signaling pathway; response to retinoic acid; negative regulation of multicellular organism growth; pharyngeal system development; in utero embryonic development; negative regulation of transcription factor activity; neural tube patterning; negative regulation of cell division; keratinocyte proliferation; spinal cord motor neuron differentiation; limb morphogenesis; organ morphogenesis; dorsal/ventral pattern formation; ureteric bud branching; response to mechanical stimulus; neural plate pattern formation; negative regulation of smoothened signaling pathway; neural tube closure; embryonic organ development; protein processing; brain development; regulation of smoothened signaling pathway. Disease: Holoprosencephaly 7; Basal Cell Nevus Syndrome; Basal Cell Carcinoma, Susceptibility To, 1

size1 :

0.02 mL

price1 :

110 USD

size2 :

0.06 mL

price2 :

150

size3 :

0.12 mL

price3 :

225

size4 :

0.2 mL

price4 :

360

more info or order :

MyBioSource product webpage