antibody

MMP15 Polyclonal Antibody

MBS2520010

0.02 mL

110 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, enzyme immunoassay

Antibody

MMP15 Polyclonal Antibody

[MMP15]

[MTMMP2, SMCP-2, MT2-MMP]

[matrix metalloproteinase-15 preproprotein; Matrix metalloproteinase-15; matrix metalloproteinase-15; MMP-15; MT-MMP 2; MT2MMP; matrix metalloproteinase 15 (membrane-inserted); membrane-type matrix metalloproteinase 2; membrane-type-2 matrix metalloproteinase; matrix metallopeptidase 15 (membrane-inserted); Membrane-type matrix metalloproteinase 2; MT-MMP 2; MTMMP2; Membrane-type-2 matrix metalloproteinase; MT2-MMP; MT2MMP; SMCP-2]

[MMP15]

[MMP15; MMP15; MTMMP2; SMCP-2; MT2-MMP; MMP-15; MT-MMP 2; MTMMP2; MT2-MMP; MT2MMP]

MMP15_HUMAN

Polyclonal

IgG

Rabbit

Human , Mouse

669

Affinity purification

Store at -20°C. Avoid freeze / thaw cycles.

ELISA (EIA), Western Blot (WB)

WB: 1:500-1:2000

Western Blot (WB)

Immunogen: Recombinant protein of human MMP15. Calculated MW: 76kDa

Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3

Cancer; Cell biology

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is amember of the membrane-type MMP (MT-MMP) subfamily; eacHuman, Mouseember of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.

4505211

BC006412

NM_002428.2

Activation Of Matrix Metalloproteinases Pathway (576264); Collagen Degradation Pathway (730309); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Matrix Metalloproteinases Pathway (198900)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008]

MMP15: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. Belongs to the peptidase M10A family. Protein type: Protease; Membrane protein, integral; EC 3.4.24.-. Chromosomal Location of Human Ortholog: 16q13. Cellular Component: extracellular matrix; integral to plasma membrane; plasma membrane. Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity; enzyme activator activity; calcium ion binding. Biological Process: positive regulation of catalytic activity; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; protein modification process; proteolysis; response to estradiol stimulus

0.02 mL

110 USD

0.06 mL

150

0.12 mL

225

0.2 mL

360